| DC21542 |
PTC-596 |
A novel, orally active, small molecule inhibitor of BMI-1 that accelerates BMI-1 degradation, inhibits AML cells growth with IC50 of <100 nM. |
|
| DC22981 |
A-37 |
A novel, potent and selective ALDH1A1 inhibitor with Ki of 300 nM and IC50 of 4.6 uM. |
|
| DC21033 |
Trilaciclib hydrochloride(G1T28)
Featured
|
A novel, potent and selective inhibitor of CDK4/6 with biochemical IC50 of 1 nM and 4 nM for CDK4/cyclin D1 and CDK6/cyclin D3, respectively. |
|
| DC20680 |
AS1604498 |
A novel, potent nicotinamide phosphoribosyl transferase (NAMPT) inhibitor with IC50 of 44 nM. |
|
| DC22533 |
Eleclazine hydrochloride
Featured
|
A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF). |
|
| DC26067 |
BI1002494 trifluoroacetate |
A novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin). |
|
| DC20439 |
LXRβ agonist 17
Featured
|
LXRβ agonist 17 is a novel, potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα; also exhibits excellent selectivity against other nuclear hormone receptors (>3,000-fold); induces the expression of LXR target genes in vitro and in vivo. |
|
| DC22699 |
JNJ-26070109 |
A novel, potent, selective orally active CCK-2 receptor antagonist with pKi of 8.49 for hCCK2. |
|
| DC11853 |
AC-73 |
A novel, specific CD147 inhibitor that can specifically disrupt CD147 dimerization, inhibits the motility and invasion of HCC cells (IC50=7-10 uM). |
|
| DC22991 |
IRES-C11 |
A novel, spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells. |
|
| DC21050 |
FN1-8
Featured
|
FN1-8 is a novel, synthetic small molecule that efficiently interferes with Gli/TAF9 interaction and downregulate Gli/TAF9-dependent transcriptional activity (at 15 uM); inhibits non-canonical Gli activation and acts downstream of the canonical Hh pathway; suppresses cancer cell proliferation in vitro and inhibits tumor growth in vivo. |
|
| DC10533 |
PKM2 inhibitor(compound 3k)
Featured
|
A novle PKM2 inhibitor inhibitor. |
|
| DC21284 |
MK-0608 |
A nucleoside analogue that shows potent inhibition for replication of several mosquito-borne flaviviruses including DENV and ZIKV. |
|
| DC23940 |
NM107
Featured
|
NM-107, also known as 2'-C-Methylcytidine; 2'-C-MeC; 2-CMC; mCyd ; 2'CMeC; 2CMC, is a a potent and selective anti-viral drug. NM-107 showed activity to inhibit the replication of foot-and-mouth disease virus. NM-107 exerts potent anti-DENV activity in DENV subgenomic RNA replicon and infectious systems, with an IC50 value of 11.2±0.3μM. NM-107 may be a promising compound for the development of direct-acting antivirals against DENV infection. |
|
| DC22384 |
Abacavir sulfate |
A nucleoside reverse transcriptase inhibitor (NRTI) that used to prevent and treat HIV/AIDS.. |
|
| DC39815 |
Tafluprost
Featured
|
Tafluprost(AFP-168) is an anti-glaucoma prostaglandin (PG) analog.A number of 17-phenyl trinor PGF2α derivatives have been approved for the treatment of glaucoma.1,2,3,4 Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency. |
|
| DC22709 |
LY3027788 |
A orally active prodrug of LY3020371, which is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively. |
|
| DC22989 |
BMS-204493
Featured
|
A pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM. |
|
| DC23094 |
TRAP-6
Featured
|
A PAR1 peptide fragment (residues 42-47) that acts as a PAR1 agonist. |
|
| DC22372 |
Dexpramipexole
Featured
|
A partial/full agonist of dopamine receptor with Ki of 3.9/2.2/0.5/5.1 nM for D2S/D2L/D3/D4, respeectively. |
|
| DC22373 |
Dexpramipexole dihydrochloride
Featured
|
Dexpramipexole 2Hcl(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value:Target: Dopamine ReceptorDexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity. |
|
| DC8496 |
CTP 518(Atazanavir, deuterated) |
A partially dueterated analog of Atazanavir, an oral HIV protease inhibitor; A deuterium-containing medicine with improved ADME properties; Compound 120 showed an approximately 50% increase in half life compared with Atazanavir. |
|
| DC22356 |
Capreomycin sulfate |
A peptide antibiotic, commonly grouped with the aminoglycosides, which is given in combination with other antibiotics for MDR-tuberculosis. . |
|
| DC23934 |
FTI-277
Featured
|
A peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM. |
|
| DC20311 |
Apraglutide
Featured
|
A peptidic glucagon like peptide 2 (GLP-2) analogue for treatment of type2 diabetes.. |
|
| DC24173 |
Tolfenpyrad |
A pesticide agent.. |
|
| DC22952 |
(S) 93-31 |
A pH-dependent, GluN2B-selective inhibitor of NMDA receptor with IC50 of 0.19 uM at pH6.9, 10-fold selecivity over brain tissue pH 7.6 (IC50=1.8 uM). |
|
| DC24170 |
TBHQ |
A phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo. |
|
| DC22501 |
Fosamprenavir calcium |
A phosphate ester prodrug of the HIV-1 protease inhibitor amprenavir with improved solubility.. |
|
| DC22845 |
Disoxaril |
A picornavirus replication inhibitor by binding to the hydrophobic pocket within the VP1 coat protein, thus stabilizing the virion and blocking its uncoating.. |
|
