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LXRβ agonist 17

  Cat. No.:  DC20439   Featured
Chemical Structure
1878259-00-7
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Field of application
LXRβ agonist 17 is a novel, potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα; also exhibits excellent selectivity against other nuclear hormone receptors (>3,000-fold); induces the expression of LXR target genes in vitro and in vivo.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1878259-00-7
Chemical Name: {2-[(2r)-4-[4-(Hydroxymethyl)-3-(Methylsulfonyl)phenyl]-2-(Propan-2-Yl)piperazin-1-Yl]-4-(Trifluoromethyl)pyrimidin-5-Yl}methanol
Synonyms: {2-[(2r)-4-[4-(Hydroxymethyl)-3-(Methylsulfonyl)phenyl]-2-(Propan-2-Yl)piperazin-1-Yl]-4-(Trifluoromethyl)pyrimidin-5-Yl}methanol;LXRbeta agonist 17;BDBM50177015;J3.604.716J;Q27456252;OCC1=C(C=C(C=C1)N1C[C@H](N(CC1)C1=NC=C(C(=N1)C(F)(F)F)CO)C(C)C)S(=O)(=O)C;2-[4-[3-(Methylsulfonyl)-4-(hydroxymethyl)phenyl]-2alpha-isopropylpiperazine-1-yl]-4-(trifluoromethyl)pyrimidine-5-methanol;67S
SMILES: S(C)(C1=C(CO)C=CC(=C1)N1CCN(C2N=CC(CO)=C(C(F)(F)F)N=2)[C@H](C(C)C)C1)(=O)=O
Formula: C21H27F3N4O4S
M.Wt: 488.52369427681
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Zheng Y, et al. J Med Chem. 2016 Apr 14;59(7):3264-71.
Description: A novel, potent, orally active liver X receptor β (LXRβ) agonist with Ki/EC50 of 3/21 nM, displays 27-fold selectivity over LXRα; also exhibits excellent selectivity against other nuclear hormone receptors (>3,000-fold); induces the expression of LXR target genes in vitro and in vivo.
References: References 1. Zheng Y, et al. J Med Chem. 2016 Apr 14;59(7):3264-71. View Related Products by Target Liver X Receptor (LXR)
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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