| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC23933 | MK-0893 | A potent, selective, reversible and competitive antagonist of glucagon receptor with high binding affinity (IC(=50=6.6 nM) and functional cAMP activity (IC50=15.7 nM). |
|
| DC20412 | II-B08 | A potent, selective, reversible inhibitor of PTP SHP2 with IC50 of 5.5 uM, exhibits >3-fold selectivity for SHP2 over other PTPs. |
|
| DC11875 | GlpG inhibitor 11 | A potent, selective, reversible rhomboid proteases inhibitor with Ki of 45 nM for GlpG . |
|
| DC22892 | KNT-127 | A potent, selectove δ-opioid receptor agonist with Ki of 0.16 nM, dispalys 133.5-fold and 960.5-fold selectivity over μOR and κOR respectively. |
|
| DC22563 | TN1 | A potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM. |
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| DC20606 | 8-Thioquinoline | A potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 2.5 uM.. |
|
| DC21321 | ML349 Featured | A potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM, >20-fold selectivity over APT-1 and serine hydrolase enzyme family. |
|
| DC22529 | FPTQ | A potent, specific and allosteric mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1, respectively.. |
|
| DC25075 | Sivelestat sodium | A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM. |
|
| DC23074 | Sivelestat Featured | A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM. |
|
| DC23494 | GRI 977143 Featured | A potent, specific and nonlipid agonist of LPA2 receptor with EC50 of 3.3 uM, does not activate any of the other LPA GPCRs (>10 uM). |
|
| DC24105 | MK-0591（Quiflapon ） Featured | A potent, specific and orally active 5-Lipoxygenase-activating protein (FLAP) inhibitor with IC50 of 1.6 nM in FLAP binding assay. |
|
| DC11556 | trans-AUCB | A potent, specific and orally bioavailable soluble epoxide hydrolase (sEH) inhibitor with IC50 of 1.3 nM. |
|
| DC21802 | VU 0364849 | A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM. |
|
| DC21807 | VU 0465350 Featured | VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM; shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy. |
|
| DC21693 | SRI-29329 | A potent, specific CDC-like kinase (CLK) inhibitor with IC50 of 78, 16 and 86 nM for CLK1, 2 and4, respectively. |
|
| DC21794 | VH 298 Featured | A potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays. |
|
| DC23985 | CHIR-99021 trihydrochloride | A potent, specific GSK-3 inhibitor with IC50 of 5 nM and 10 nM for GSK3β and GSK3α, respectively. |
|
| DC21150 | PR-924 | A potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM). |
|
| DC21773 | UK-101 | A potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey. |
|
| DC21527 | PR-893 | A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 17 nM, 21-fold and 13-fold selectivity for β5 over LMP7 and LMP2 subunits, respecitvely.. |
|
| DC21365 | NC-005 | A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely. |
|
| DC21528 | PR-825 | A potent, specific immunoproteasome β5 subunit inhibitor.. |
|
| DC24007 | R-1479 Featured | A potent, specific inhibitor of HCV NS5B polymerase and HCV replication (IC50=1.28 uM, replicon assay). |
|
| DC22758 | SI-113 | A potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells. |
|
| DC20998 | ES 936 | A potent, specific mechanism-based human NAD(P)H: quinone oxidoreductase 1 (NQO1) inhibitor that demonstrates efficient inactivation of NQO1 at 100 nM in in cellular systems. |
|
| DC22823 | Tariquidar methanesulfonate hydrate | A potent, specific P-gp inhibitor with Kd of 5.1 nM. |
|
| DC21849 | YU-101 | A potent, specific proteasome β5 subunit inhibitor with IC50 of 0.26 uM, 7.3 and 17.3-fold selectivity over β2i and β1i subunit, respecitvely.. |
|
| DC26068 | BMS-753 | A potent, specific RARα agonist with Ki of 2 nM, displays no significant effects on RARγ in reporter based assays.. |
|
| DC22661 | AB1 | A potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs. |
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