| DC11875 |
GlpG inhibitor 11 |
A potent, selective, reversible rhomboid proteases inhibitor with Ki of 45 nM for GlpG . |
|
| DC22892 |
KNT-127 |
A potent, selectove δ-opioid receptor agonist with Ki of 0.16 nM, dispalys 133.5-fold and 960.5-fold selectivity over μOR and κOR respectively. |
|
| DC22563 |
TN1 |
A potent, small molecule fetal hemoglobin (HbF) inducer with EC50 of 100 nM. |
|
| DC20606 |
8-Thioquinoline |
A potent, small molecule inhibitor of the proteasome subunit Rpn11 with IC50 of 2.5 uM.. |
|
| DC21321 |
ML349
Featured
|
A potent, specific acyl protein thioesterase 2 (APT-2, LYPLA2) inhibitor with IC50 of 144 nM and Ki of 120 nM, >20-fold selectivity over APT-1 and serine hydrolase enzyme family. |
|
| DC22529 |
FPTQ |
A potent, specific and allosteric mGluR1 antagonist with IC50 of 6 nM and 1.4 nM for human and mouse mGluR1, respectively.. |
|
| DC25075 |
Sivelestat sodium |
A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM. |
|
| DC23074 |
Sivelestat
Featured
|
A potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM. |
|
| DC23494 |
GRI 977143
Featured
|
A potent, specific and nonlipid agonist of LPA2 receptor with EC50 of 3.3 uM, does not activate any of the other LPA GPCRs (>10 uM). |
|
| DC24105 |
MK-0591（Quiflapon ）
Featured
|
A potent, specific and orally active 5-Lipoxygenase-activating protein (FLAP) inhibitor with IC50 of 1.6 nM in FLAP binding assay. |
|
| DC11556 |
trans-AUCB |
A potent, specific and orally bioavailable soluble epoxide hydrolase (sEH) inhibitor with IC50 of 1.3 nM. |
|
| DC21802 |
VU 0364849 |
A potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 5.4 nM. |
|
| DC21807 |
VU 0465350
Featured
|
VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM; shows no activity for ALK2/4/5, also shows affinity for TGFBR2, VEGFR2 and AMPK; blocks SMAD phosphorylation in vitro and in vivo, and enhances liver regeneration after partial hepatectomy. |
|
| DC21693 |
SRI-29329 |
A potent, specific CDC-like kinase (CLK) inhibitor with IC50 of 78, 16 and 86 nM for CLK1, 2 and4, respectively. |
|
| DC21794 |
VH 298
Featured
|
A potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays. |
|
| DC23985 |
Laduviglusib trihydrochloride
Featured
|
Laduviglusib (CHIR-99021) trihydrochloride is a well-characterized small molecule inhibitor that specifically targets glycogen synthase kinase-3 alpha and beta (GSK-3α/β). It exhibits potent inhibitory activity with IC50 values of 10 nM for GSK-3α and 6.7 nM for GSK-3β. Importantly, it demonstrates high selectivity, being over 500-fold more selective for GSK-3 compared to other kinases such as CDC2 and ERK2, as well as a broad range of other protein kinases. |
|
| DC21150 |
PR-924 |
A potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM). |
|
| DC21773 |
UK-101 |
A potent, specific immunoproteasome β1i (LMP2) subunit inhibitor with IC50 of 104 nM, 144- and 10-fold selectivity over β1c and β5 subunit respectivey. |
|
| DC21527 |
PR-893 |
A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 17 nM, 21-fold and 13-fold selectivity for β5 over LMP7 and LMP2 subunits, respecitvely.. |
|
| DC21365 |
NC-005 |
A potent, specific immunoproteasome β5 subunit inhibitor with IC50 of 44 nM, 105 and 225-fold selectivity over β2i and β1i subunit, respecitvely. |
|
| DC21528 |
PR-825 |
A potent, specific immunoproteasome β5 subunit inhibitor.. |
|
| DC24007 |
R-1479
Featured
|
A potent, specific inhibitor of HCV NS5B polymerase and HCV replication (IC50=1.28 uM, replicon assay). |
|
| DC22758 |
SI-113 |
A potent, specific inhibitor of the SGK1 kinase activity, induces autophagy, apoptosis and ER stress in cancer cells. |
|
| DC20998 |
ES 936 |
A potent, specific mechanism-based human NAD(P)H: quinone oxidoreductase 1 (NQO1) inhibitor that demonstrates efficient inactivation of NQO1 at 100 nM in in cellular systems. |
|
| DC22823 |
Tariquidar methanesulfonate hydrate |
A potent, specific P-gp inhibitor with Kd of 5.1 nM. |
|
| DC21849 |
YU-101 |
A potent, specific proteasome β5 subunit inhibitor with IC50 of 0.26 uM, 7.3 and 17.3-fold selectivity over β2i and β1i subunit, respecitvely.. |
|
| DC26068 |
BMS-753 |
A potent, specific RARα agonist with Ki of 2 nM, displays no significant effects on RARγ in reporter based assays.. |
|
| DC22661 |
AB1 |
A potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs. |
|
| DC24060 |
YM-155 hydrochloride
Featured
|
A potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM. |
|
| DC22864 |
KSP-IA |
A potent, specific, allosteric and cell-active inhibitor of KSP with IC50 of 11 nM. |
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