Cat. No. | Product name | CAS No. |
DC7465 |
MK-2206 2HCl
Featured
MK-2206 2HCl is a highly selective inhibitor of Akt1/2/3 with IC50 of 8 nM/12 nM/65 nM, respectively; no inhibitory activities against 250 other protein kinases observed. Phase 2. |
1032350-13-2 |
DC11405 |
MK-3903
Featured
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM. generation of catalytically active enzyme. |
1219737-12-8 |
DC12020 |
MK-8722
Featured
MK-8722 is a systemic, Direct Pan-Activator of AMP-Activated Protein Kinase. |
1394371-71-1 |
DC10871 |
MTX211
Featured
MTX-211 is a dual inhibitor of EGFR and PI3K, used for the treatment of cancer and other diseases. |
1952236-05-3 |
DC7250 |
NVP-BAG956(BAG 956)
NVP-BAG956(BAG 956) is a potent, ATP-competitive and selective dual PI3K and PDK1 inhibitor in vitro and in vivo,with IC50 values to be 56, 444, 34, 117 and 240 nM for PI3K p110 alpha, beta, delta and gamma and PDK1 kinases, respectively. |
853910-02-8 |
DC3133 |
NVP-BGT226 (BGT226)
Featured
NVP-BGT226 is a novel dual PI3K/mTOR inhibitor with IC50 of 1 nM. |
1245537-68-1 |
DC10540 |
NVP-BQR695
Featured
NVP-BQR695 is a novel PI3K inhibitor. |
1513879-21-4 |
DC1006 |
OSI-027
Featured
OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. |
936890-98-1 |
DC7220 |
OSU-03012
Featured
OSU-03012(AR-12) is a potent inhibitor of recombinant PDK-1 with IC50 of 5 μM and 2-fold increase in potency over OSU-02067. |
742112-33-0 |
DC8732 |
OTSSP167
Featured
OTSSP167 is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like). |
1431697-89-0 |
DC7475 |
OTSSP167 HCl
Featured
OTSSP167 is a highly potent MELK inhibitor (IC50 = 0.41 nM) and inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like). |
1431698-10-0 |
DC9587 |
PDK1 inhibitor
PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent.. |
1001409-50-2 |
DC2021 |
Perifosine (KRX-0401)
Featured
Perifosine (KRX-0401) is a novel Akt inhibitor with IC50 of 4.7 μM. |
157716-52-4 |
DC8527 |
PF-04979064
PF-04979064 is a highly potent and orally bioavailable PI3K/mTOR dual inhibitor developed through structure-based drug design. It inhibited mTOR, PI3Kα, β, δ and γ isoforms and AKT phosphorylation with IC50 as 2.64 nM, 0.395 nM, 0.111 nM, 0.122 nM and 28. |
1220699-06-8 |
DC11466 |
PF-06409577
Featured
PF-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 isoform with an EC50 of 7 nM. |
1467057-23-3 |
DC8395 |
PF-4989216
Featured
PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively. |
1276553-09-3 |
DC7481 |
PHT427
Featured
PHT-427 is a dual Akt and PDPK1 inhibitor (high affinity binding for the PH domains of Akt and PDPK1) with Ki of 2.7 μM and 5.2 μM, respectively. |
1191951-57-1 |
DC7232 |
PI-103
Featured
PI103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha (IC50= 2 nM), p110beta (IC50= 3 nM), p110delta (IC50= 3 nM), and p110gamma (IC50= 15 nM), less potent to mTOR/DNA-PK with IC50 of 30 nM/23 nM. |
371935-74-9 |
DC7628 |
PI-3065
Featured
PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR. |
955977-50-1 |
DC8335 |
PQR-309(Bimiralisib)
Featured
PI3K-IN-2 is a PI3K inhibitor, inhibits pPKB and pS6 with "++++/+++(+)" in A2058 melanoma cell. |
1225037-39-7 |
DC9661 |
PIK-293
Featured
PIK-293 is a PI3K inhibitor, mostly for PI3Kδ with IC50 of 0.24 μM, 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively. |
900185-01-5 |
DC7234 |
PIK-294
Featured
PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively. |
900185-02-6 |