| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC9706 | ABT-639 Featured | ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. ABT-639 blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion (IC50 = 2 μM) and attenuates LVA currents in rat DRG neurons (IC50 = 8 μM). |
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| DC10723 | ABT-702 Featured | ABT-702 is a potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). |
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| DC9262 | ABT-719 Featured | ABT-719 is a potent bacterial DNA gyrase inhibitor. |
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| DC9261 | ABT-719 HCl Featured | ABT-719 is a potent bacterial DNA gyrase inhibitor. |
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| DC1022 | ABT-737 Featured | ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively. |
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| DC7353 | ABT-751(E 7010) Featured | ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. |
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| DC4231 | Linifanib (ABT-869) Featured | ABT-869 is an ATP-competitive, multi-targeted RTK inhibitor that is completely effective against all members of the vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF) receptor families. |
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| DC20630 | ABTL0812 | ABTL0812 is a novel first-in-class, small molecule that inhibits the Akt/mTORC1 axis and shows antiproliferative effect on tumor cells. |
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| DC11155 | ABX-1431 Featured | ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL). |
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| DC11183 | ABX-1431 hydrochloride Featured | ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL). |
|
| DC23182 | ABX464 Featured | ABX464 (ABX-464, ABX 464) is a novel class of anti-HIV small molecule targeting Rev-mediated viral RNA biogenesis, shows dose dependent inhibition of HIV-1 replication in stimulated PBMCs with IC50 of 0.1-0.5 uM. |
|
| DC7698 | AC 55541 Featured | AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 6.7) that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. |
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| DC11508 | AC1903 Featured | AC1903 is a specific and selective inhibitor of TRPC5 and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model. |
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| DC10293 | AC260584 | AC260584 is an M1 muscarinic receptor allosteric agonist with a pEC50 of 7.6. |
|
| DC11149 | AC261066 | AC261066 (AC-261066, AC261) is a potent, selective, orally available RARβ2 agonist with pEC50 of 8.1, displays selectivity over RARβ1, RARα and RARγ (pEC50=6.4, 6.2 and 6.3). |
|
| DC12577 | AC-263093 Featured | AC-263093 (AC263093) is a potent, functionally selective neuropeptide FF receptor type 2 (NPFFR2) agonist with pKi of 6.9. |
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| DC10117 | AC264613 Featured | AC264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). Displays no activity at other PAR subtypes and exhibits no significant activity at over 30 other receptors implicated in nociception and inflammation. |
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| DC20631 | AC-265347 | AC-265347 is a calcimimetic acting agent and highly efficacious, orally active allosteric agonist (PAM) of CaSR with IC50 of 10 nM in PI hydrolysis assays. |
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| DC20300 | AC-4-130 | AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3. |
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| DC21863 | AC5 inhibitor C90 | AC5 inhibitor C90 is a novel potent, selective adenylyl cyclase type 5 (AC5) inhibitor with IC50 of 30 nM, >5-fold selectivity over AC2 and AC6 subtypes. |
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| DC12086 | AC-55649 Featured | AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9. |
|
| DC7700 | AC710 Featured | AC710, is a potent Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases. |
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| DC12492 | N-(p-Amylcinnamoyl) anthranilic Acid (ACA) Featured | ACA is a cell permeable inhibitor of PLA2,reported to inhibit α-ketoisocaproic acid and glyceraldehyde-induced insulin secretion, as well as glucose-induced insulin secretion. |
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| DC9917 | Acacetin Featured | Acacetin is an O-methylated flavone found in Robinia pseudoacacia (black locust), Turnera diffusa (damiana),Betula pendula (silver birch),and in the fern Asplenium normale. |
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| DC7047 | AICAR (Acadesine) Featured | Acadesine results in accumulation of ZMP, which mimics the stimulating effect of AMP on AMPK and AMPK kinase. Phase 3. |
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| DC9660 | Acalabrutinib(ACP196) Featured | Acalabrutinib (ACP-196) is a second-generation, selective, irreversible inhibitor of BTK. |
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| DC8760 | Acalisib Featured | Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ with IC50 value of 12.7 nM. |
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| DC22280 | Acarbose Featured | Acarbose is the first identified α-glucosidase inhibitor. |
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| DC11458 | Ac-DEVD-pNA(Caspase-3 Substrate) Featured | Ac-DEVD-pNA is a colorimetric substrate for caspase-3 (CPP32) (Km=9.7μM) and related cysteine proteases. |
|
| DC11359 | Caspase-3 Substrate | Ac-DNLD-AMC is a fluorogenic caspase-3 substrate. |
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