DC20427 |
JH-XI-10-02 |
JH-XI-10-02 is a CDK8 PROTAC based on the CDK8 inhibitor JH-VIII-49, induces partial degradation of CDK8 in Jurkat cells with IC50 of 159 nM.. |
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DC22122 |
JI051
Featured
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JI051(JI-051) is a specific compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression. |
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DC10123 |
JI-101
Featured
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JI-101 is an oral multi-kinase inhibitor that targets vascular endothelial growth factor receptor type 2 (VEGFR-2), platelet derived growth factor receptor β (PDGFR-β), and ephrin type-B receptor 4 (EphB4). |
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DC22123 |
JI130 |
JI130 (JI-130) is a specific Hse1 inhibitor that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone, blocks Hes1-mediated transcriptional repression. |
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DC7437 |
JIB-04
Featured
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JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively. |
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DC9929 |
JK-184
Featured
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JK-184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). |
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DC20428 |
JKA3 inhibitor 31 |
JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases. |
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DC10595 |
JK-P3
Featured
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JK-P3 is a VEGFR-2 inhibitor. |
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DC21204 |
JM6 |
JM6 (KMO inhibitor JM6) is an orally bioavailable small-molecule prodrug of Ro 61-8048, which is an inhibitor of kynurenine 3-monooxygenase (KMO). |
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DC10971 |
JMS-17-2
Featured
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JMS-17-2 is a potent and selective antagonist of CX3CR1 with IC50 of 0.32 nM, displays significant selectivity for CX3CR1 over other chemokine receptors such CXCR2, CXCR1, and CXCR4 (IC50>1 uM). |
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DC21167 |
JMV 2959
Featured
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JMV 2959 (AEZS-123) is a potent ghrelin receptor (GHS-R1A) antaognist with binding IC50 of 32 nM. |
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DC21168 |
JNc-440 |
JNc-440 is a small molecule that significantly and specifically strengthens the TRPV4-KCa2.3 interaction in mouse endothelial cells, but does not systemically activate TRPV4 and KCa2.3. |
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DC12804 |
JND3229
Featured
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JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM). |
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DC23538 |
JNJ 10181457 dihydrochloride |
JNJ 10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3. |
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DC23539 |
JNJ 10181457 |
JNJ 10181457 is a neutral, potent and selective, brain penetrant H3 antagonist with pKi of 8.93, pA2 of 9.22 for hH3. |
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DC23418 |
JNJ 39220675 |
JNJ 39220675 is potent and selective, brain penetrant H3 antagonist with Ki of 1.4 nM, pA2 of 9.42 for hH3. |
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DC7843 |
JNJ 42153605
Featured
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JNJ 42153605 is a positive allosteric modulator of the metabotropic glutamate 2 receptor. |
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DC11404 |
JNJ0966
Featured
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JNJ0966 is a highly selective compound
that inhibited activation of MMP-9 zymogen and subsequent
generation of catalytically active enzyme. |
|
DC21171 |
JNJ-10198409 |
JNJ-10198409 is a highly potent, selective PDGFRβ inhibitor with IC50 of 4.2 nM. |
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DC12374 |
JNJ-10229570
Featured
|
JNJ-10229570 (JNJ10229570) is a novel potent, selective melanocortin receptor MC1R and MC5R antagonist with binding IC50 of 270 nM and 200 nM, respectively. |
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DC23504 |
JNJ16567083 |
JNJ16567083 (EMQMCM) is a potent and selective mGluR1 antagonist that shows neuroprotective effects in some hypoxia-ischemia models. |
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DC7617 |
JNJ-1661010 |
JNJ-1661010 is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2. |
|
DC22665 |
JNJ18038683
Featured
|
JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays. |
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DC22717 |
JNJ-18038683 free base |
JNJ-18038683 is a potent, selective 5-HT7 receptor antagonist with pKi of 8.19 and 8.20 for rat and human 5-HT7 in cell-based assays. |
|
DC21910 |
JNJ-1A |
JNJ-1A is a novel Dengue virus (DENV) NS4B inhibitor that inhibits DENV-2 sub-genomic replicon at 0.7 μM, in the absence of cytotoxicity. |
|
DC11115 |
JNJ-26489112 |
JNJ-26489112 (JNJ26489112) is a broad-spectrum anticonvulsant that displays activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. |
|
DC7175 |
JNJ-26854165 (Serdemetan)
Featured
|
JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. |
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DC21172 |
JNJ-26993135 |
JNJ-26993135 is a potent, selective leukotriene A4 hydrolase (LTA4H) inhibitor, inhibits both the epoxide hydrolase and aminopeptidase activities of recombinant human LTA4H with IC50 of 10 nM. |
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DC22716 |
JNJ-28307474 |
JNJ-28307474 is a potent, selective antagonist of the histamine H4 receptor (H4R), inhibits LPS-induced TNF production.. |
|
DC21173 |
JNJ-28312141 hydrochloride |
JNJ-28312141 is a potent, orally active CSF-1 receptor (CSF-1R) kinase inhibitor with IC50 of 0.69 nM. |
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