DC10882 |
JNJ-632
Featured
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JNJ-632 is a novel and potent inhibitor of HBV replication in vitro across genotypes A-D. |
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DC9271 |
JNJ-63533054
Featured
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JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM. |
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DC7178 |
JNJ-7706621
Featured
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JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6; also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1. |
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DC8773 |
JNJ-7777120
Featured
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JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors. |
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DC23273 |
JPC-3210 |
JPC-3210 is a potent antimalarial agent with IC50 of 2.5-19 nM, remains activity against multidrug-resistant Plasmodium falciparum lines with little cytotoxicity in mammalian cell lines. |
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DC22516 |
Unii-cedo9qxyzk
Featured
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JPH203 (KYT-0353) is a potent, selective L-type amino acid transporter 1 (LAT1, SLC7A5) inhibitor with IC50 of 60 nM (leucine uptake inhibition), but not LAT2. |
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DC11080 |
JPI-289 |
JPI-289 (JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM. |
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DC21911 |
JQ1-VHL-PROTAC |
JQ1-VHL-PROTAC is a novel PROTAC synthesis.. |
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DC12191 |
JQ-35-(S)
Featured
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JQ-35, (S)- is an inhibitor of the Bromodomain and Extra-Terminal (BET) family bromodomain-containing proteins with potential antineoplastic activity. |
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DC11421 |
JQEZ5
Featured
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JQEZ5 is a novel and potent EZH2 inhibitor. |
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DC12640 |
JSF-4088 |
JSF-4088 (JSF4088) is a novel antitubercular agent with potent in vitro antitubercular potency (MIC=19 nM), with no significant Vero cell cytotoxicity (CC50 >120 uM).. |
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DC12422 |
JSH-150
Featured
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JSH-150 (JSH150) is a potent, highly selective inhibitor of CDK9 kinase with IC50 of 1 nM in the biochemical assays, displays 300-10000-fold selectivity over other CDK kinase family members (CDK7 IC50=1.72 uM). |
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DC7741 |
JSH-23
Featured
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JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM. |
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DC10607 |
JTE-013
Featured
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JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. |
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DC26081 |
JTE-852
Featured
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JTE-852 is a novel potent, selective, ATP-competitive Syk kinase inhibitor with IC50 of 1.25/1.28 nM for human/rat Syk, respectively. |
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DC22128 |
JTE-952 |
JTE-952 (JTE952) is a potent, selective colony stimulating factor-1 receptor (CSF1R) type II inhibitor with IC50 of 14 nM, shows cellular activity in BMMCs IL-6 secretion assays with IC50 of 20 nM. |
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DC21188 |
JTP-117968 |
JTP-117968 is a novel orally available, selective glucocorticoid receptor modulator (SGRM) with IC50 of 6.8 nM. |
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DC11190 |
JTT-551 |
JTT-551 (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR. |
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DC11191 |
JTT-551 sodium |
JTT-551 sodium (JTT551, JTT 551) is a novel potent, selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) with Ki of 0.22 uM, displays >45-fold and >136-fold selectivity over TCPTP, CD45 and LAR. |
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DC21189 |
JTT-553 |
JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM). |
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DC21190 |
JTT-553 benzosulfonate |
JTT-553 is a novel potent, selective DGAT-1 inhibitor with IC50 of 2.38 nM, shows no inhibitory activity for human DGAT2 and ACA T1 (IC50>10 uM). |
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DC21193 |
JTV-519 |
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs). |
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DC21195 |
JTV-519 hydrochloride |
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs). |
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DC21194 |
JTV-519 fumarate |
JTV-519 (K201) is a Ca2+-dependent blocker of SERCA and a partial agonist of ryanodine receptors (RyRs). |
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DC23761 |
Juniferdin |
Juniferdin is a small molecule, potent Protein disulfide isomerase (PDI) inhibitor with IC50 of 156 nM, inhibits PDI-mediated reduction of HIV-1 envelope glycoprotein gp120. |
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DC21191 |
JVW-1034 |
JVW-1034 is a selective small molecule modulator of σ2R/Tmem97 with Ki of 23 nM, 10-fold weaker affinity for σ1R (Ki=248 nM). |
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DC7169 |
JW55
Featured
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JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively. |
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DC22448 |
JW 642 |
JW 642 (JW642) is a potent, selective monoacylglycerol lipase (MAGL) inhibitor with IC50 of 7.6, 14 and 3.7 nM for mouse, rat and human MAGL, respectively. |
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DC20429 |
JW-7-25-1 |
JW-7-25-1 is a potent MELK inhibitor with biochemical IC50 of 5.0 nM, also inhibits PIK3CA, mTOR, GSK3A and CDK7 with CI50 of 5-60 nM. |
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DC21628 |
JYL-1421 |
JYL-1421 (SC-0030) is a potent, competitive TRPV1 receptor antagonist with Ki of 53.5 nM, antagonizes capsaicin-induced calcium uptake with EC50 of 9.2 nM. |
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