Novel potent inhibitor of the CREBBP/EP300 bromodomain, showing >100-fold selectivity over a representative member of the BET bromodomains, BRD4(1)

BAY-9835 is the first orally bioavailable ADAMTS7 inhibitor with IC50 of 6 nM, which is selective against a range of off-targets and metalloproteases except for ADAMTS12.

Natural modulator of miRNA biogenesis, inhibiting the proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cells

Subtype-selective activator of K(Ca)2.1

MM 07 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart.

AAcid-PEG5-C2-Boc is a PEG derivative containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Novel inhibitor of cholesterol transport proteins

Antitumor agent to be associated with negative regulation of Met endosomal signaling in renal cancer cells

Inhibitor of Eukaryotic Translation; Antitumor Natural Product

Moderate alpha-l-fucosidase inhibitor

Natural microbial metabolite of isoflavone genistein, increasing the lifespan and improving the thermal and oxidative stress tolerance of C. elegans

Less active enantiomer of Elexacaftor

BAY-805 is a potent and selective USP21 inhibitor. BAY-805 is a non-covalent inhibitor with low nanomolar affinity for USP21 and high selectivity over other DUB targets as well as kinases, proteases, and other common off-targets.

Metabolite of VX-740

Vesicular monoamine transporter-2 (VMAT2) inhibitor, with 15-​fold greater affinity than GZ-​793A

Inactive control for VinSpinIn

Negative control for EED inhibitor EED226

Negative control compound for UNC3866 which is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains

FIT-039 is a potent, selective CDK9 inhibitor with IC50 of 5.8 uM for CKD9/cyclin T1, suppresses the replication of HSV-1 (IC50=0.69 uM).

Negative control for UCSF924

Cell impermeant homolog of UCD38B, inhibitor of uPA (urokinase plasminogen activator)

Negative control for TP-004

Negative control for TP-238

Negative control for TP-040

Negative control for THPP-1

Novel potent and selective NUDT15 inhibitor (MG IC50 = 35 nM), potentiating the anti-HCMV efficacy of ganciclovir

Negative control for TH1760

Metabolite of Telmisartan

Novel novel anti-tuberculosis (TB) agent, possessing improved safety properties compared to bedaquiline