| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC22966 | ABH hydrochloride Featured | A potent, selective human Arginase inhibitor with Ki of 0.25 uM (pH=7.5), 8.5 nM (pH=9.5) for type II arginase. |
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| DC11857 | BAY-8040 (R) Featured | Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension. |
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| DC22454 | IMPDH2-IN-5 | A potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with IC50 of 620 nM (inhibition of NO production). |
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| DC20345 | CLK inhibitor 2 | A potent, selective inhibitor of cdc2-like kinase CLK1 and CLK2 with IC50 of 1.1 and 2.4 nM, respectively. |
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| DC11644 | Pitstop 1 | A potent, selective inhibitor of clathrin-independent endocytosis with IC50 of 18 uM (inhibition of clathrin TD-amphiphysin B/C complex formation). |
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| DC11700 | Chalcone 4 hydrate | A potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM. |
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| DC22897 | KRH-1636 | A potent, selective inhibitor of CXCR4 with IC50 of 13 nM, has no effect on CXCR1, CCR3, CCR4, or CCR5. |
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| DC22847 | L-870810 | A potent, selective inhibitor of HIV integrase (IC50=8-15 nM) with potent antiviral activity in cell culture and good pharmacokinetic properties. |
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| DC11706 | R-10015 Featured | A potent, selective inhibitor of human LIMK1 with IC50 of 38 nM . |
|
| DC23189 | CL-82198 Featured | CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression. |
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| DC22658 | Windorphen | A potent, selective inhibitor of p300 histone acetyltransferase (IC50=4.2 uM). |
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| DC22625 | Rolipram Featured | A potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. |
|
| DC23910 | Microcystin-LR | A potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM. |
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| DC11967 | PF-06649298 | A potent, selective inhibitor of the Na+/citrate transporter NaCT (SLC13A5) that shows inhibition of citrate uptake in the HEKNaCT cells with IC50 of 0.41 uM. |
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| DC22754 | SKA-111 | A potent, selective intermediate-conductance KCa3.1 positive-gating modulator with EC50 of 111 nM. |
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| DC23551 | PF-05388169 | A potent, selective IRAK4 inhibitor with IC50 of 0.094 nM, >500-fold selectivity over IRAK1 (IC50=65 nM). |
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| DC23550 | PF-05387252 | A potent, selective IRAK4 inhibitor with IC50 of 1.3 nM, 200-fold selectivity over IRAK1 (IC50=290 nM). |
|
| DC11507 | CLP257 Featured | CLP257 (CLP-257) is a potent, selective K+-Cl- cotransporter KCC2 activator with EC50 of 616 nM; displays selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, and a panel of 55 other receptors; restores impaired Cl(-) transport i |
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| DC22677 | (±)-U-50488 hydrochloride | A potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects. |
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| DC11503 | KDOAM-25 Featured | A potent, selective KDM5 sub-family(JARID1) inhibitor with biochemical IC50 of 71/19/69/69 nM for KDM5A/B/C/D, respectively. |
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| DC11650 | Ro5-4864 Featured | A potent, selective ligand for the mitochondrial translocator protein 18kDa (TSPO/PBR). |
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| DC22858 | LIMK-IN-14 | A potent, selective LIMK inhibitor with IC50 of 0.9 nM and 0.5 nM and 1.2 nM for LIMK1 and LIMK2, respectively. |
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| DC22859 | LIMK-IN-22j | A potent, selective LIMK inhibitor with IC50 of 3.2 nM and 1.2 nM for LIMK1 and LIMK2, respectively. |
|
| DC24026 | LPA2-IN-1 | A potent, selective LPA2 (EDG4) antagonist with IC50 of 17 nM. |
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| DC22364 | DG051 | A potent, selective LTA4H (Leukotriene A4 hydrolase) inhibitor (IC50/Kd=47/25 nM) of leukotriene B4 biosynthesis. |
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| DC20722 | AZD-1979 | A potent, selective melanin concentrating hormone receptor 1 (MCH-R1) antagonist with binding Ki of 12.2 nM. |
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| DC26072 | BMS 819881 | A potent, selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 10.4 nM. |
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| DC22710 | LY3020371 hydrochloride | A potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively. |
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| DC22921 | AMN 082 | A potent, selective mGluR7 allosteric agonist that inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64±32 nM. |
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| DC11630 | ND-378 | A potent, selective MMP-2 inhibitor with Ki of 230 nM. |
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