| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC23927 | MIM1 | A potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1. |
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| DC23623 | PF-06761281 Featured | A potent, selective sodium-coupled citrate transporter (NaCT or SLC13A5) with IC50 of 0.51 uM, >20-fold selectivity over NaDC1 and NaDC3. |
|
| DC26089 | MNS | A potent, selective Src and Syk kinase inhibitor with IC50 of 29.3 uM and 2.5 uM, respectively. |
|
| DC20557 | STAT3 inhibitor C188 | A potent, selective STAT3 inhibitor that blocks STAT3 binding to its phosphopeptide ligand (IC50=20 uM) and inhibits IL-6-mediated phosphorylation of STAT3. |
|
| DC20375 | Erasin | A potent, selective STAT3 inhibitor with IC50 of 9.7 uM, inhibits tyrosine phosphorylation of STAT3 with selectivity over STAT5 and STAT1 in cell-based assays. |
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| DC20824 | BP-5-087 | A potent, selective STAT3 SH2 domain inhibitor (EC50=5.6 uM) that reduces STAT3 phosphorylation and nuclear transactivation. |
|
| DC21580 | RO 5166017 | A potent, selective TAAR1 agonist with Ki of 1.9, 2.7, 31 and 24 nM for mouse, rat, cynomolgus monkey and human TAAR1 stably expressed in HEK293 cells. |
|
| DC20593 | 5Z-7-Oxozeaenol | A potent, selective TAK1 inhibitor with IC50 of 8 nM, displays >33-fold and >62-fold selectivity over MEKK1 and MEKK4 respectively. |
|
| DC22578 | TPO-Agonist-1 | A potent, selective thrombopoietin (TPO) receptor agonist.. |
|
| DC23548 | TLR9 inhibitor 18 | A potent, selective TLR9 antagonist with IC50 of 13 nM (human TLR9), displays 75-fold selectivity over TLR7 and no activity against TLR8 (IC50>10 uM). |
|
| DC20878 | CDK7 and 9 inhibitor 14 | A potent, selective transcriptional CDK inhibitor with Ki of 2.3 and 0.38 nM for CDK7 and CDK9, respectively. |
|
| DC22786 | CB34 | A potent, selective translocator protein 18 kDa (TSPO/PBR) agonist with IC50 of 2.59 and 1.03 nM in competing with [3H]-PK11195 for binding to membrane preparations from rat cerebral cortex and ovary, respectively. |
|
| DC21220 | Larixyl acetate | A potent, selective TRPC6 channel inhibitor with IC50 of 0.1-0.6 uM, 12- and 5-fold selectivity over related TRPC3 and TRPC7. |
|
| DC21820 | WS-12 | A potent, selective TRPM8 agonist with EC50 of 12 uM, a cooling agent. |
|
| DC24043 | USP8-IN-22e Featured | A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.28 uM. |
|
| DC24042 | USP8-IN-22c | A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.56 uM. |
|
| DC24041 | USP8-IN-22d | A potent, selective ubiquitin-specific protease USP8 inhibitor with IC50 of 0.85 uM. |
|
| DC22696 | BRL 44408 Featured | A potent, selective α2A-adrenoceptor antagonist with Ki of 1.7 nM, 80-fold selectivity over α2B-adrenergic receptors. |
|
| DC22695 | BRL 44408 maleate | A potent, selective α2A-adrenoceptor antagonist with Ki of 1.7 nM, 80-fold selectivity over α2B-adrenergic receptors. |
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| DC22694 | ARC 239 dihydrochloride | A potent, selective α2B adrenoceptor antagonist with pKd of 8.8, 200-fold selectivity over α2A, and α2D receptors. |
|
| DC22536 | CFMTI Featured | A potent, selective, allosteric and oral mGluR1 antaognist with IC50 of 2.6 and 2.3 nM for human and rat mGluR1, respectively. |
|
| DC22753 | NS13001 Featured | A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively. |
|
| DC11745 | BMS-22 | A potent, selective, allosteric CCR2 antagonist with binding IC50 of 5.1 nM. |
|
| DC11744 | CCR2-RA-[R] | A potent, selective, allosteric CCR2 antagonist with IC50 of 103 nM.. |
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| DC21316 | ML400 | A potent, selective, allosteric LMPTP inhibitor with IC50 of 1.68 uM, displays good selective against other phosphatases. |
|
| DC22916 | JNJ-10397049 | A potent, selective, and bioavailable OX2 receptor antagonist with Kb of 4.5 nM. |
|
| DC23971 | LY450108 | A potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors.. |
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| DC24030 | LY451395 Featured | A potent, selective, and centrally active positive allosteric modulator of AMPAR-mediated neurotransmission, which increase ion channel flux in the presence of agonist by suppressing desensitization and/or deactivation of the receptors.. |
|
| DC23963 | QL-47 | A potent, selective, and irreversible BTK inhibitor with IC50 of 7 nM. |
|
| DC21545 | PXS-4681A | A potent, selective, and irreversible inhibitor of SSAO/VAP-1 (AOC3) with Ki of 37 nM, IC50 of <10 nM. |
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