| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC11850 | MK-7145 | A potent, selective, and oral renal outer medullary potassium channel (ROMK) inhibitor with IC50 of 68 nM. |
|
| DC11727 | RO-2468 | A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 6 nM. |
|
| DC11728 | RO-5353 | A potent, selective, and orally active p53-MDM2 antagonist with IC50 of 7 nM. |
|
| DC21254 | LY-517717 | A potent, selective, and orally bioavailable factor Xa (FXa) inhibitor for prevention and treatment of thromboembolic diseases.. |
|
| DC21487 | PF-05190457 Featured | A potent, selective, and orally bioavailable ghrelin receptor (GHSR) inverse agonist with binding pKi of 8.36. |
|
| DC23541 | IRAK4-IN-16 | A potent, selective, and orally bioavailable inhibitor of interleukin-1 receptor-associate kinase-4 (IRAK4) with IC50 of 2.8 nM, 217- and 892-fold selectivity over IRAK-1 and TAK1, respectively. |
|
| DC23949 | CX-6258 hydrochloride hydrate | A potent, selective, and orally efficacious pan-Pim inhibitor with IC50 of 5/25/16 nM for Pim1/2/3, respectively. |
|
| DC23036 | BI-69A11 | A potent, selective, ATP competitive AKT inhibitor with IC50 of 2.3 uM for Akt1. |
|
| DC22651 | PF-4950834 | A potent, selective, ATP-competitive and orally acitve Rho kinase inhibitor with IC50 of 33.1 and 8.5 nM for ROCK1 and ROCK2, respectively. |
|
| DC23867 | PF-00337210 | A potent, selective, ATP-competitive and orally bioavailable inhibitor of VEGFR-2 with Ki of 0.7 and 8.8 nM for unactivated and fully phosphorylated VEGFR-2, respectively. |
|
| DC11711 | VER-158411 | A potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively. |
|
| DC11733 | SAR-020106 | A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM. |
|
| DC12007 | SOMG-833 | A potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM. |
|
| DC23930 | Bay 65-1942 | A potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM. |
|
| DC22500 | Bay 65-1942 hydrochloride | A potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM. |
|
| DC23070 | MAP4K4-IN-11e | A potent, selective, ATP-competitive inhibitor of MAP4K4 with IC50 of 1.9 uM, without effect on other stress pathway related kinases. |
|
| DC23964 | BMS-509744 | A potent, selective, ATP-competitive ITK inhibitor with IC50 of 19 nM. |
|
| DC22551 | DFMTI | A potent, selective, brain penetrant and orally active mGluR1 antagonist with 4.3 nM and 3.6 nM for huam and rat mGluR1, respectively. |
|
| DC22895 | VU0477573 | A potent, selective, brain penetrant partial negative allosteric modulator of mGlu5 receptor with Ki of 14 nM, Ca assay IC50 of 32 nM. |
|
| DC22964 | PQ-10 Featured | A potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM. |
|
| DC11660 | PF-4181366 | A potent, selective, brain penetrant PDE9A inhibitor with IC50 of 1.8 nM. |
|
| DC23695 | PF-05085727 | A potent, selective, brain penetrant phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 2 nM, >4,000-fold selectivity over PDE1 and PDE3-11. |
|
| DC22920 | AMN 082 dihydrochloride | A potent, selective, brain penetrant, orally acitve mGluR7 allosteric agonist that inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64±32 nM. |
|
| DC23640 | ASP2535 | A potent, selective, brain permeable, orally available glycine transporter-1 (GlyT1) inhibitor with IC50 of 92 nM (rat GlyT1), 50-fold selectivity over GlyT2. |
|
| DC11895 | Foliglurax hydrochloride | A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
|
| DC11894 | Foliglurax | A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
|
| DC20549 | SHP2 inhibitor 11a-1 | A potent, selective, cell active SHP2 inhibitor with IC50 of 200 nM, displays >5-fold selectivity against 20 other mammalian PTPs. |
|
| DC11948 | CK2 inhibitor D11 | A potent, selective, cell permeab anti-apoptotic protein kinase CK2 with Ki of 5 nM. |
|
| DC11858 | BAY-678 Featured | BAY-678 is a cell-permeable inhibitor of human neutrophil elastase (HNE). |
|
| DC22877 | CPI703 | A potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.47 uM for CBP. |
|
