| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC23596 | Luseogliflozin | A potent, selective, orally acitve SGLT2 inhibitor with IC50 of 2.26 nM, 1650-fold selectivity over SGLT1. |
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| DC21307 | MKC-733 | A potent, selective, orally active 5-HT3 receptor agonist with high affinity for canine intestinal smooth muscle 5-HT3 receptors. |
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| DC11667 | PF-592379 | A potent, selective, orally active agonist of dopamine D3 receptor with EC50 of 21 nM. |
|
| DC21606 | SB-357134 | A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes. |
|
| DC20774 | VTP 37948 | A potent, selective, orally active BACE1 inhibitor for the treatment of Alzheimer's disease.. |
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| DC20665 | AMG 8718 | A potent, selective, orally active BACE1 inhibitor with IC50 of 0.7 nM, demonstrates limited selectivity for over BACE2 and high selectivity both renin and pepsin. |
|
| DC20324 | BRS-3 agonist Compound A | A potent, selective, orally active bombesin receptor subtype-3 (BRS-3) agonist with EC50 of 250/100 nM for human/rat BRS-3, resp+H1437+M1438. |
|
| DC20325 | BRS-3 agonist Compound A racemate | A potent, selective, orally active bombesin receptor subtype-3 (BRS-3) agonist with EC50 of 270/130 nM for human/rat BRS-3, respectively. |
|
| DC21187 | JTE907 Featured | A potent, selective, orally active cannabinoid CB2 receptor inverse agonist with Ki of 35.9, 1.55 and 0.38 nM for human, mouse and rat CB2, respectively. |
|
| DC21793 | VER-250840 | A potent, selective, orally active Chk1 inhibitor with IC50 of < 1 nM, Ki=69 pM. |
|
| DC22898 | L-365260 | A potent, selective, orally active cholecystokinin receptor 2 (CCK2) antagonist with IC50 of 2 nM. |
|
| DC22485 | Gefitinib hydrochloride Featured | A potent, selective, orally active EGFR inhibitor with IC50 of 23 nM. |
|
| DC21443 | ONO-5334 | A potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. |
|
| DC23340 | CCT-251455 | A potent, selective, orally active monopolar spindle 1 (MPS1) inhibitor with IC50 of 3 nM, with no activity for CDK2 and Aurora A (IC50>40 uM). |
|
| DC11704 | CFI-401870 | A potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM. |
|
| DC25200 | PF-1355 Featured | PF-1355 is a potent, selective, orally active Myeloperoxidase (MPO) inhibitor with EC50 of 1.47 uM. |
|
| DC22900 | MLE-4901 Featured | A potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of schizophrenia. |
|
| DC22664 | Fezolinetant Featured | Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes. |
|
| DC22686 | SCH 221510 | A potent, selective, orally active nociceptin opioid receptor (NOP) agonist with EC50 of 12 nM, Ki of 0.3 nM. |
|
| DC21276 | Seltorexant | A potent, selective, orally active orexin-2 receptor (OX2R) antagonist with pKi of 8.0 and 8.1 for human and rat OX2R, respectively. |
|
| DC21148 | IPI-443 | A potent, selective, orally active p110δ/γ PI3K dual inhibitor with cellular IC50 of 0.29 and 7.1 nM, respectively. |
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| DC20681 | AS1940477 | A potent, selective, orally active p38α/p38β inhibitor with IC50 of 11.2/36.5 nM respectively, with no effect on p38γ and δ isoforms (IC50>1 uM). |
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| DC23441 | CS-0777 | A potent, selective, orally active S1P receptor-1 (S1P1) agonist with EC50 of 1.1 nM, 320-fold selectivity over S1P3. |
|
| DC25065 | NIBR 0213 Featured | A potent, selective, orally active S1P1 antagonist with IC50 of 2.5 nM Ca2+ mobilization assays, without activity on S1P2, S1P3 and S1P4 (IC50>10 uM). |
|
| DC21287 | MK-4256 | A potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 0.66 nM, >500-fold selectivity over SSTR1/2/4/5. |
|
| DC21295 | MK-1421 | A potent, selective, orally active somatostatin receptor SSTR3 antagonist with binding Ki of 2.3 nM, >2,500-fold selectivity over SSTR1/2/4/5 (IC50>5 uM). |
|
| DC21579 | RO 5073012 | A potent, selective, orally active TAAR1 partial agonist with Ki of 6 nM, EC50 of 23 nM (hTAAR1), 140-fold selectivity over β2 adrenergic receptors. |
|
| DC20654 | AM-0902 Featured | A potent, selective, orally active TRPA1 channel antagonist with IC50 of 71 and 131 nM for rTRPA1 and hTRPA1 in Ca2+ flux assays respectively, without agonist activity (EC50>40 uM). |
|
| DC21179 | JNJ 41876666 | A potent, selective, orally active TRPM8 channel antaognist with IC50 of 0.8 nM, . |
|
| DC11615 | γ-secretase modulator 14a | A potent, selective, orally active γ-secretase modulator with Aβ42 IC50 of 39 nM. |
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