| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC25052 | Src I338G-IN-3g | A potent, selective, cell-permeable I338G v-Src inhibitor with IC50 of 430 nM, shows no inhibition of wild-type v-Src at 300 uM. |
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| DC21474 | PF-04781340 | A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability. |
|
| DC22708 | VU 0255035 | A potent, selective, CNS penetrant and competitive orthosteric antagonist of M1 mAChR with IC50 of 132 nM, >75-fold selectivity over M2-M5. |
|
| DC22667 | mGlu5 PAM 4k | A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM. |
|
| DC22684 | JNJ-46778212 Featured | A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM. |
|
| DC11558 | DLK-IN-14 | A potent, selective, CNS penetrant dual leucine zipper kinase (DLK, MAP3K12) inhibitor with Ki of 3 nM. |
|
| DC11870 | RORγt-IN-9a | A potent, selective, CNS penetrant, orally bioavailable RORγt with pIC50 of 8.3 in FRET assays. |
|
| DC22730 | JNJ-42253432 | A potent, selective, CNS-penetrant P2X7 antagonist with pKi of 9.1 and 7.9 for rat and huamn P2X7 channel, respectively. |
|
| DC22903 | SW-106 Featured | SW106 is a potent, selective, competitive PTH/PTH-related peptide receptor (PPR) antagonist with IC50 of 0.99 uM. |
|
| DC11898 | Gosogliptin | A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM. |
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| DC11899 | Gosogliptin dihydrochloride | A potent, selective, competitive, orally active dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 13 nM. |
|
| DC23069 | KRAS G12C inhibitor 1 | A potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.. |
|
| DC21442 | ONO 2050297 | A potent, selective, dual CysLT1 and CysLT2 antagonist with IC50 of 17 and 0.87 nM, respectively.. |
|
| DC11666 | BMS-470539 | A potent, selective, full agonist of human and murine MC1R with EC50 of 16.8 and 11.6 nM, respectively. |
|
| DC20736 | AZD 9272 | A potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM. |
|
| DC20723 | AZD 2066 | A potent, selective, highly CNS-penetrant mGluR5 antagonist. |
|
| DC11721 | PF-06747775 | A potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively. |
|
| DC22679 | CM 572 | A potent, selective, irreversible sigma-2 receptor partial agonist with Ki of 14.6 nM, >700-fold selectivity over sigma-1 receptors. |
|
| DC23412 | BMS-955829 | A potent, selective, low glutamate fold shift (2.4) mGluR5 positive allosteric modulator with EC50 of 2.6 nM, without inherent mGluR5 agonist activity (EC50>30 uM). |
|
| DC22804 | CMPD-1 | A potent, selective, non-ATP-competitive inhibitor of p38α-mediated MK2a phosphorylation with apparent Ki of 330 nM. |
|
| DC22742 | KAB-18 | A potent, selective, noncompetitive human α4β2 nAChRs negative allosteric modulator with IC50 of 13.5 uM, displays no inhibitory activity on Hα3β4 nAChRs at 100 uM.. |
|
| DC23195 | CBR-5884 Featured | A potent, selective, noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) with IC50 of 7 uM. |
|
| DC11746 | JNJ-27141491 | A potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM. |
|
| DC22449 | PD-146176 | A potent, selective, non-competitve inhibitor of 15-lipoxygenase (15-LOX) with Ki of 197 nM. |
|
| DC22447 | FAAH-IN-2 | A potent, selective, noncovalent FAAH inhibitor with IC50 of 28 nM toward human FAAH and 100 nM toward rat FAAH. |
|
| DC11756 | SR 140333 | A potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM. |
|
| DC22680 | Conivaptan | A potent, selective, nonpeptide vasopressin V1A and V2 receptor antagonist with Ki of 0.48 nM and 3.04 nM respectively. |
|
| DC21738 | TBC3486 | A potent, selective, non-peptidic integrin α4β1 (VLA-4) antagonist with IC50 of 9 nM, displays 200-fold selectivity over α4β7 (IC50=2.1 uM). |
|
| DC20617 | AA-CW236 Featured | A potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency. |
|
| DC21593 | RUC-4 Featured | A potent, selective, non-RGD-mimetic αIIbβ3 integrin receptor antagonist with IC50 of 45 nM, with no activity on αVβ3 receptors. . |
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