| DC44685 |
MS-PEG3-THP |
MS-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44686 |
Benzyl-PEG7-THP |
Benzyl-PEG7-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44687 |
Benzyl-PEG6-THP |
Benzyl-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44688 |
Bis-CH2-PEG2-acid |
Bis-CH2-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44689 |
Amino-PEG7-t-butyl ester |
Amino-PEG7-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44690 |
Thiol-PEG2-t-butyl ester |
Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44691 |
Methyl-PEG4-acyl chloride |
Methyl-PEG4-acyl chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44692 |
Azido-PEG9-S-methyl ethanethioate |
Azido-PEG9-S-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44693 |
Azido-PEG5-S-methyl ethanethioate |
Azido-PEG5-S-methyl ethanethioate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44694 |
Methyl-PEG3-Ald |
Methyl-PEG3-Ald is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44695 |
Propargyl-PEG9-acid |
Propargyl-PEG9-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44696 |
Thiol-C9-PEG4-acid |
Thiol-C9-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44697 |
Nonylbenzene-PEG8-OH |
Nonylbenzene-PEG8-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44698 |
Bromo-PEG7-azide |
Bromo-PEG7-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44699 |
t-Butyl acetate-PEG2-CH2COOH |
t-Butyl acetate-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44700 |
Cyclohexane-PEG1-Br |
Cyclohexane-PEG1-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44701 |
BocNH-PEG5-CH2CH2Br |
BocNH-PEG5-CH2CH2Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC44702 |
Tos-PEG3-CH2COOtBu |
Tos-PEG3-CH2COOtBu is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC53120 |
XD2-149
Featured
|
XD2-149 is a napabucasin PROTAC as an effective degrader of the E3 ligase ZFP91 with IC50 of 1 μM and 0.8 μM in pancreatic cancer cell lines, MIA PaCa-2 and BxPC-3, respectively. XD2-149 also reduces the expression of STAT3, pSTAT3, and NQO1 proteins. |
|
| DC44798 |
ARV-110
Featured
|
ARV-110 is an orally active, specific androgen receptor (AR) PROTAC degrader. ARV-110 promotes ubiquitination and degradation of AR. ARV-110 can be used for the research of prostate cancer. |
|
| DC44905 |
Vepdegestrant (ARV-471)
Featured
|
ARV-471 is a best-in-class, orally active estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer. |
|
| DC45199 |
PROTAC BRD4 Degrader-10 |
PROTAC BRD4 Degrader-10 (compound 8b) is a potent BRD4 degrader. PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 1.3 nM and 18 nM, respectively. |
|
| DC45200 |
PROTAC BRD4 Degrader-12 |
PROTAC BRD4 Degrader-12 (compound 9c) is a potent chimeric BRD4 degrader. PROTAC BRD4 Degrader-12 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.39 nM and 0.24 nM, respectively. |
|
| DC45201 |
PROTAC BRD4 Degrader-13
Featured
|
PROTAC BRD4 Degrader-13 (compound 9d) is a potent chimeric BRD4 degrader. PROTAC BRD4 Degrader-13 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.025 nM and 6.0 nM, respectively. |
|
| DC45202 |
PROTAC BRD4 Degrader-11 |
PROTAC BRD4 Degrader-11 (compound 9a) is a potent chimeric BRD4 degrader. PROTAC BRD4 Degrader-11 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.23 nM and 0.38 nM, respectively. |
|
| DC45203 |
PROTAC BRD4 Degrader-14 |
PROTAC BRD4 Degrader-14 is a potent BRD4 degrader, with IC50s of 1.8 nM and 1.7 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-14 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells. |
|
| DC45204 |
PROTAC BRD4 Degrader-8 |
PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells. |
|
| DC45205 |
PROTAC BRD4 Degrader-9 |
PROTAC BRD4 Degrader-9 (compound 8a) is a potent BRD4 degrader. PROTAC BRD4 Degrader-9 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.86 nM and 7.6 nM, respectively. |
|
| DC45206 |
Bis-sulfone-PEG4-DBCO |
Bis-sulfone-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45207 |
Azido-PEG2-propargyl |
Azido-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
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