| DC45238 |
Propargyl-PEG7-amine |
Propargyl-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45239 |
m-PEG5-amino-Mal |
m-PEG5-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45240 |
Propargyl-PEG7-Br |
Propargyl-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45241 |
Mal-amido-PEG5-acid |
Mal-amido-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45242 |
Azido-PEG7-NHS ester |
Azido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45243 |
Propargyl-PEG11-amine |
Propargyl-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45244 |
Propargyl-PEG11-acid |
Propargyl-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45245 |
Mal-PEG10-acid |
Mal-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45246 |
Propargyl-PEG12-acid |
Propargyl-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45247 |
Propargyl-PEG13-OH |
Propargyl-PEG13-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45248 |
Mal-amido-PEG7-NHS ester |
Mal-amido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45249 |
Mal-PEG10-Boc |
Mal-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45250 |
Mal-PEG10-NHS ester |
Mal-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45251 |
Propargyl-PEG13-Boc |
Propargyl-PEG13-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45252 |
m-PEG14-NHS ester |
m-PEG14-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45253 |
Fmoc-PEG9-NHS ester |
Fmoc-PEG9-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45254 |
Fmoc-PEG10-NHS ester |
Fmoc-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45255 |
Bis-sulfone-PEG4-Tetrazine |
Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45256 |
Azido-PEG10-propargyl |
Azido-PEG10-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45257 |
Benzyl-PEG10-Ots |
Benzyl-PEG10-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
|
| DC45258 |
Benzyl-PEG12-Ots |
Benzyl-PEG12-Ots is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. |
|
| DC55003 |
XY028-140 (MS140)
Featured
|
XY028-140 (MS-140) is a potent and selective PROTAC-based CDK4/CDK6 kinase degrader. XY028-140 specifically inhibits RB-E2F signaling and reduces CDK4 and CDK6 protein levels in a dose- and time-dependent manner in vitro. In addition, XY028-140 can degrade its targets by linking them with ubiquitin-proteasome mechanism. Further, the degradation of CDK4/6 protein by XY028-140 is specifically mediated by CRBN. Therefore, XY028-140 effectively and selectively inhibits and degrades CDK4/6 kinase by targeting CDK4/6 kinase in CDK4/6i-S (CDK4/6 inhibitor-sensitive) tumor cells to the CRL4-CRBN-E3 ubiquitin complex. Compared with CDK6 wild-type cells, XY028-140 treatment of cells expressing wild-type or mutation-activated CDK6 resulted in a more effective degradation of CDK6 (S178P). |
|
| DC45754 |
ACBI1
Featured
|
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis. |
|
| DC45755 |
Bis-PEG12-endo-BCN |
Bis-PEG12-endo-BCN is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC45756 |
5-Boc-amino-pentanoic acid |
5-Boc-amino-pentanoic acid (Boc-5-aminovaleric acid, Boc-NH-C4-acid, Boc-5-Ava-OH) is a PROTAC linker that belongs to a Alkyl/ether linker. Boc-NH-C4-acid is applicable to the synthesis of PROTAC1, and specifically degrades EED, EZH2, and SUZ12 in the PRC2 Complex. |
|
| DC45853 |
PROTAC BRD4 Degrader-15 |
PROTAC BRD4 Degrader-15 is a potent BRD4 degrader, with IC50s of 7.2 nM and 8.1 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-15 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells. |
|
| DC45855 |
PROTAC IRAK4 degrader-4 |
PROTAC IRAK4 degrader-4 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127. |
|
| DC45856 |
PROTAC IRAK4 degrader-6 |
PROTAC IRAK4 degrader-6 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-172. |
|
| DC46178 |
PROTAC KRAS G12C degrader-1 |
PROTAC KRAS G12C degrader-1 is a PROTAC-based KRASG12C degrader, with an IC50 of 414 nM for CRBN. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells. |
|
| DC46179 |
PROTAC Bcl-xL ligand-1 |
PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs. |
|
