| DC46222 |
BET-IN-6 |
BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4, and is used for the systhesis of PROTAC BRD2/BRD4 degrader-1.
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| DC46308 |
Ipatasertib-NH2 dihydrochloride |
Ipatasertib-NH2 dihydrochloride is a ligand for target protein AKT for PROTAC (INY-03-041). INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase. |
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| DC46309 |
Boc-piperazine-benzoic acid
Featured
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Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128. |
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| DC46369 |
GSK215
Featured
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GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader. GSK215 is designed by a binder for the VHL E3 ligase and the FAK inhibitor VS-4718. GSK215 induces rapid and prolonged FAK degradation, giving a long-lasting effect on FAK levels and a marked pharmacokinetic/pharmacodynamics (PK/PD) disconnect. |
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| DC46405 |
ARD-2128
Featured
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ARD2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader. ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer. |
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| DC46448 |
Mal-PEG2-NH2 TFA |
Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC46475 |
PROTAC Bcl-xL degrader-1 |
PROTAC Bcl-xL degrader-1 is a PROTAC that comprises a Bcl-xL ligand binding group, a linker and an IAP E3 ligases binding group. PROTAC Bcl-xL degrader-1 is a potent Bcl-xL degrader, and shows toxicity for human platelets and MyLa 1929 cells with IC50 values of 62 nM and 8.5 μM, respectively. |
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| DC46573 |
BzNH-BS |
BzNH-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and benzoyl-amide, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase. |
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| DC46575 |
PROTAC ER Degrader-2 |
PROTAC ER Degrader-2 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). |
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| DC46576 |
SNIPER(ABL)-019 |
SNIPER(ABL)-019, conjugating Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM. |
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| DC46577 |
SNIPER(ABL)-044 |
SNIPER(ABL)-044, conjugating HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 μM. |
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| DC46578 |
SNIPER(ABL)-049 |
SNIPER(ABL)-049, conjugating Imatinib (ABL inhibitor) to Bestatin (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 100 μM. |
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| DC46579 |
SNIPER(TACC3)-1 |
SNIPER(TACC3)-1 targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway. SNIPER(TACC3)-1 induces cancer cell death. |
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| DC46580 |
SNIPER(TACC3)-2 |
SNIPER(TACC3)-2 targets the TACC3 protein for degradation via the ubiquitin-proteasome pathway. SNIPER(TACC3)-2 induces cancer cell death. |
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| DC47072 |
PROTAC PTK6 ligand-1 |
PROTAC PTK6 ligand-1 is an intermediate for BTK kinase inhibitor preparation. PROTAC PTK6 ligand-1 can be used in the synthesis of ARD-61.
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| DC47193 |
OICR-9429-N-C2-NH2 |
OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs. |
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| DC47212 |
Boc-bipiperidine-ethynylbenzoic acid |
Boc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61. |
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| DC47213 |
L-Homopropargylglycine hydrochloride |
L-Homopropargylglycine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-homopropargylglycine hydrochloride is an amino acid analog of methionine containing an alkyne moiety that can undergo a classic click chemical reaction with azide containing Alexa Fluor. |
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| DC47319 |
Dovitinib-RIBOTAC |
Dovitinib RIBOTAC is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity. |
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| DC47369 |
Propargyl-PEG2-CH2COOH |
Propargyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC47370 |
Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) |
Biotinyl-NH-PEG3-C3-amido-C3-COOH (DIPEA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. |
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| DC47371 |
1-Bromo-6-chlorohexane |
1-Bromo-6-chlorohexane is a PROTAC linker can be used in the synthesis of PROTACs. |
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| DC47372 |
Bromo-C10-OBn |
Bromo-C10-OBn is a PROTAC linker that can be used in the synthesis of PROTACs. |
|
| DC47584 |
PROTAC BRD4 ligand-2 |
PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718. |
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| DC47585 |
PROTAC CDK9 ligand-1 |
PROTAC CDK9 ligand-1 is a CDK9 ligand that can be used in the synthesis of PROTACs. |
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| DC47878 |
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH |
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
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| DC47879 |
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH |
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
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| DC47885 |
TLR4-IN-C34-C2-amide-C6-OH |
TLR4-IN-C34-C2-amide-C6-OH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis. |
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| DC48040 |
Biotin-PEG8-Vidarabine |
Biotin-PEG8-Vidarabine is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses. |
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| DC48041 |
Biotin-PEG7-C2-S-Vidarabine |
Biotin-PEG7-C2-S-Vidarabine is a PEG-based linker that incorporates adenosine analog Vidarabine. Vidarabine is an antiviral agent which is active against herpes simplex and varicella zoster viruses. |
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