Cat. No. | Product name | CAS No. |
DC8401 |
BI-847325
Featured
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1. |
1207293-36-4 |
DC7098 |
BI-D1870
Featured
BI-D1870 is a small molecule, specific inhibitor of p90 RSK (ribosomal S6 kinase) isoforms RSK1, RSK2, RSK3 and RSK4, both in vitro and in vivo, with IC50s are 31 nM, 24 nM, 18 nM, 15 nM, respectively. |
501437-28-1 |
DC7836 |
Doramapimod (BIRB-796)
Featured
BIRB 796 (Doramapimod) is a highly selective p38α MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKCα/β/γ. |
285983-48-4 |
DC5002 |
BIX02188 (BIX 02188)
Featured
BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
334949-59-6 |
DC5003 |
BIX02189 (BIX 02189)
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. |
1265916-41-3 |
DC7718 |
B-Raf IN 1
Featured
B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM). |
950736-05-7 |
DC8921 |
B-Raf inhibitor 1
Featured
B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 0.31 uM and 2 nM for A375 proliferation and A375 p-ERK respectively. |
1093100-40-3 |
DC7008 |
BRAF inhibitor
Featured
BRAF inhibitor is a potent BRAF inhibitor. |
918505-61-0 |
DC7096 |
CC-401
Featured
CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. |
1438391-30-0 |
DC10005 |
CCT196969
Featured
CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. |
1163719-56-9 |
DC8777 |
CEP-32496 hydrochloride
CEP-32496 Hcl is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. |
1227678-26-3 |
DC8196 |
CEP-32496
Featured
CEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. |
1188910-76-0 |
DC7381 |
CGP-57380
Featured
CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 (IC50 = 2.2 μM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. |
522629-08-9 |
DC2088 |
CI-1040 (PD184352)
Featured
CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM. |
212631-79-3 |
DC9617 |
CMK
CMK is a RSK2 kinase inhibitor. |
821794-90-5 |
DC9555 |
Cot inhibitor-2
Cot inhibitor-2 is a COT/Tpl2 inhibitor. |
915363-56-3 |
DC5149 |
Dabrafenib
Featured
Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Phase 3. |
1195765-45-7 |
DC4103 |
Dabrafenib Mesylate
Featured
Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. |
1195768-06-9 |
DC8866 |
DEL-22379
Featured
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM. |
181223-80-3 |
DC9755 |
eFT508(Tomivosertib)
Featured
Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance. |
1849590-01-7 |
DC7696 |
FMK
Featured
Fmk is an irreversible ribosomal S6 kinase inhibitor 1/2 inhibitor. |
821794-92-7 |
DC3102 |
GDC-0879
GDC-0879 is a novel potent, selective B-Raf inhibitor for B-RafV600E with IC50 of 0.13 nM. |
905281-76-7 |