Ras-Raf-MAPK-ERK

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Cat. No.	Product Name	Field of Application
DC8812	LJI-308 Featured	LJI308 is a selective and potent RSK inhibitor.
DC7711	Losmapimod Featured	Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. Phase 3.
DC10828	LXH254 Featured	LXH254 is a potent CRAF inhibitor extracted from patent WO2018051306A1, Compound A. LXH254 also is a potent BRAF inhibitor.
DC8630	Ralimetinib 2MsOH(LY2228820) Featured	LY2228820 is a novel and potent p38MAPK inhibitor (the IC50 for p38αMAPK and p38βMAPK were 7 nM and 3 nM, respectively).
DC7943	LYS6K2(LY2584702) tosylate salt Featured	LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.
DC8344	LY3009120 Featured	LY3009120 is a potent and selective pan-RAF inhibitor with potential anticancer activity.
DC10640	LY3214996 Featured	LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines.
DC10751	M2698 Featured	M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier.
DC7467	ML-098 Featured	ML-098 is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) that demonstrates selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).
DC11829	MW-150 Featured	MW-150 is a novel potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM
DC11828	MW-150 hydrochloride	MW-150 is a novel potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM
DC9817	Necrosulfonamide (NSA) Featured	Necrosulfonamide (NSA) is a very specific and potent necrosis inhibitor with an IC50 less than 0.2 uM.
DC8787	NQDI-1 Featured	NQDI-1 is a specific inhibitor of ASK1 (IC50 = 3 μM; Ki = 500 nM) that demonstrates potent selectivity against various serine/threonine and tyrosine protein kinases.
DC7963	NSC-23766 free base Featured	NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.
DC8725	NSC 23766 Featured	NSC 23766 is a specific inhibitor of the binding and activation of Rac GTPase.
DC8043	OTS514 Featured	OTS-514 is a novel TOPK(PDZ binding kinase; PBK) inhibitor. IC50:2.6nM
DC7723	OTS964， OTS 964 Featured	OTS964 is a novel TOPK(T–lymphokine-activated killer cell–originated protein kinase) inhibitor.
DC9681	Pamapimod（R-1503） Featured	Pamapimod（R-1503）is a novel p38 MAP kinase inhibitor.
DC10199	Pan-RAS-IN-1	Pan-RAS-IN-1 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors.
DC5100	PD 98059 Featured	PD 98059 is a selective inhibitor of MEK and blocker of MAPK
DC1056	PD0325901 (Mirdametinib) Featured	PD0325901 (PD325901) is selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM.
DC5095	PD169316 Featured	PD169316 is a potent and selective p38 MAP kinase inhibitor
DC8744	PD318088 Featured	PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site.
DC10496	PF06260933 Featured	PF 06260933 is a potent and selective MAP4K4 inhibitor (IC50 value 3.7 nM for MAP4K4 a.k.a. HGK or ZC1) with suitable PK properties in mouse to be used as a tool in an in vivo model of diabetes, vascular inflammation and atherosclerosis.
DC8727	PF-04880594 Featured	PF-04880594 is an inhibitor of RAF with IC50 values of 0.19 nM/0.13 nM and 0.39 nM for BRAF/BRAFV599E and c-RAF, respectively.
DC1071	Vemurafenib (PLX4032) Featured	PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM.
DC6301	PLX-4720 Featured	PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.
DC9814	PLX7904(PB04) Featured	PLX7904(PB04) is a potent and selective paradox-breaker RAF inhibitor.
DC7370	AZ-628 Featured	Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM For c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity For Raf kinases over a panel of 150 other kinases.
DC5049	RAF265 (CHIR-265) Featured	RAF265 (CHIR-265) is a highly selective B-Raf and VEGFR2 inhibitor with IC50 of 3-60 nM and EC50 of 30 nM, including B-Raf, C-Raf and mutant B-Raf.

Ras-Raf-MAPK-ERK

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