Ras-Raf-MAPK-ERK

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Cat. No.	Product Name	Field of Application
DC7096	CC-401 Featured	CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
DC10005	CCT196969 Featured	CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity.
DC8777	CEP-32496 hydrochloride	CEP-32496 Hcl is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.
DC8196	CEP-32496 Featured	CEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFRβ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.
DC7381	CGP-57380 Featured	CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 (IC50 = 2.2 μM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.
DC2088	CI-1040 (PD184352) Featured	CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM.
DC9617	CMK	CMK is a RSK2 kinase inhibitor.
DC9555	Cot inhibitor-2	Cot inhibitor-2 is a COT/Tpl2 inhibitor.
DC5149	Dabrafenib Featured	Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Phase 3.
DC4103	Dabrafenib Mesylate Featured	Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity.
DC8866	DEL-22379 Featured	DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM.
DC9755	eFT508(Tomivosertib) Featured	Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.
DC7696	FMK Featured	Fmk is an irreversible ribosomal S6 kinase inhibitor 1/2 inhibitor.
DC3102	GDC-0879	GDC-0879 is a novel potent, selective B-Raf inhibitor for B-RafV600E with IC50 of 0.13 nM.
DC4177	Cobimetinib(GDC-0973; XL518) Featured	GDC-0973 is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase, also known as MEK, a serine/threonine kinase that is a component of the RAS/RAF/MEK/ERK pathway.
DC10106	GNE-3511 Featured	GNE-3511 is a potent and selective zipper kinase (DLK, MAP3K12) inhibitors.
DC10546	GNE-495 Featured	GNE-495 is a potent and Selective MAP4K4 Inhibitor with IC50 of 3.7 nM.
DC8810	GW-5074 Featured	GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM); displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms.
DC10503	GW806742X Featured	GW806742X is a novel VEGFR inhibitor.
DC9694	IQ-1S Featured	IQ-1S is a selective JNK3 inhibitor (IC50 values are 390, 360 and 87 nM for JNK1, 2 and 3 respectively).
DC11240	KBFM123	KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM).
DC10487	KO947 Featured	KO-947 is a small molecule inhibitor of extracellular-signal-regulated kinases 1 and 2 (ERK1/2), as a potential treatment for cancers in which the mitogen activated protein kinase (MAPK) pathway.
DC11223	KRAS inhibitor C6ME	KRAS inhibitor C6ME is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V in vitro..
DC11222	KRAS inhibitor Cmpd2	KRAS inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro.
DC7793	K RAS INHIBITOR-12 Featured	K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).
DC9906	K-Ras-IN-1 Featured	K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.
DC8362	L-779,450 Featured	L-779,450 is a potent, ATP-competitive Raf (Raf kinase) inhibitor (IC50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.
DC7018	LGX-818(Encorafenib) Featured	LGX818 is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.
DC10099	BGB283	Lifirafenib（BGB-283） is a Novel potent and selective RAF Kinase and EGFR inhibitor.
DC8811	LJH-685 Featured	LJH685 is a selective and potent RSK inhibitor.

Ras-Raf-MAPK-ERK

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