DC8840 |
CB-5083
Featured
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CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . |
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DC8042 |
CB-839(Telaglenastat)
Featured
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CB-839 is a potent, selective, reversible and orally bioavailable inhibitor of human glutaminase. |
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DC10617 |
CBL0137
Featured
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CBL0137 is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. |
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DC8377 |
CC-115
Featured
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CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. |
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DC10146 |
CC-122(Avadomide)
Featured
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CC-122 is a novel agent for DLBCL with antitumor and immunomodulatory activity.CC-122 binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL. |
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DC8497 |
CC-223
Featured
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CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3Kα (IC50=4 μM). |
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DC7096 |
CC-401
Featured
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CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. |
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DC10206 |
CCX140 |
CCX140 is a potent CCR2 antagonist. |
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DC3170 |
Cediranib
Featured
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Cediranib (AZD2171) is a highly potent VEGFR2 inhibitor with IC50 of 0.5 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM. |
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DCAPI1024 |
Cefditoren pivoxil |
Cefditoren pivoxil |
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DC10357 |
Cenerimod |
Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM. |
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DC9765 |
CERC-501(LY-2456302,Aticaprant)
Featured
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CERC-501(LY-2456302) is a potent, selective antagonist of the kappa opioid receptor (KOR) (Ki = 0.81 nM vs. 24.0 nM and 155 nM for the μ-opioid receptor (MOR) and δ-opioid receptor (DOR), respectively. |
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DC9154 |
Cetirizine 2HCl |
Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. |
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DC10440 |
Namodenoson (CF-102)
Featured
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CF-102(2-Cl-IB-MECA) is a selective A3 adenosine receptor agonist (Ki = 0.33 nM). Displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively.
target: A3 adenosine receptor agonist; |
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DC8471 |
CGS 21680 hydrochloride
Featured
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CGS 21680 hydrochloride is an A2A adenosine receptor agonist (Ki = 27 nM). |
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DC8418 |
CH5183284 (Debio-1347)
Featured
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CH5183284 is a selective and orally available FGFR inhibitor with IC50 of 9.3 nM, 7.6 nM, 22 nM, and 290 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Phase 1. |
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DC7383 |
CH5424802(Alectinib)
Featured
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CH5424802(AF 802; Alectinib) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. |
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DC8728 |
CH5424802(Alectinib HCl)
Featured
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CH5424802(AF 802; Alectinib) is a potent ALK inhibitor with IC50 of 1.9 nM, sensitive to L1196M mutation. |
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DC7978 |
Tucidinostat(Chidamide)
Featured
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Chidamide is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8; also inhibits HDAC10/11(IC50=78/432 nM); no inhibition on HDAC4/5/7/9/6(IC50>30 uM). |
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DC8116 |
Tosedostat (CHR2797)
Featured
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CHR-2797 is an aminopeptidase inhibitor, with IC50 values of 100 nM for LAP3 (LAP), 150 nM for PSAP (PuSA) and 220 nM for CD13 (Aminopeptidase N). |
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DC10341 |
CHZ868 |
CHZ868 is a type II JAK2 inhibitor with an IC50 of 0.17 μM in EPOR JAK2 WT Ba/F3 cell. |
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DC2088 |
CI-1040 (PD184352)
Featured
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CI-1040 (PD 184352) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM. |
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DC2060 |
CI994 (Tacedinaline)
Featured
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CI994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM. |
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DCAPI1021 |
Cidofovir(Vistide)
Featured
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Cidofovir(Vistide) |
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DCAPI1569 |
Cilostazol |
Cilastazol is a 2-oxo-quinoline with vasodilator, antimitogenic, antithrombotic, and cardiotonic properties. This compound has been shown to cause inhibition of adenosine uptake, eventually resulting in changes to cAMP levels. Studies have shown Cilostazo |
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DC9160 |
Cilnidipine
Featured
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Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity. |
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DC10868 |
Cilofexor
Featured
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Cilofexor (GS-9674, GS9674) is novel specific, non-steroidal farnesoid X receptor (FXR) agonist that reduces liver fibrosis and ameliorates portal hypertension in rat NASH models. |
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DC9582 |
Cilomilast |
Cilomilast(SB 207499; Ariflo) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. |
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DC8801 |
Cinacalcet (AMG-073)
Featured
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Cinacalcet(AMG-073) is an orally active, second-generation calcimimetic compound; AMG 073 represents a new class of compounds for the treatment of hyperparathyroidism. |
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DC9174 |
Cinepazide maleate |
Cinepazide Maleate is a vasodilator. |
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