| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC10012 | Pirmenol hydrochloride Featured | Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM. |
|
| DC9465 | Pitolisant (hydrochloride) Featured | Pitolisant Hcl(BF2.649;Ciproxidine ) is a novel, potent, and selective nonimidazole inverse agonist at the recombinant human H3 receptor (Ki=0.16 nM). |
|
| DC7634 | PKC-412 (Midostaurin) Featured | PKC-412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity. |
|
| DC7238 | Gedatolisib(PKI-587) Featured | PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM and <0.1 μM for PI3K-α and mTOR, respectively. |
|
| DC10016 | Pleconarilis Featured | Pleconarilis is a picornavirus replication inhibitor. |
|
| DC5055 | Plerixafor (AMD3100) Featured | Plerixafor is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
|
| DC8741 | Plerixafor octahydrochloride Featured | Plerixafor octahydrochloride(AMD3100 8HCL) is a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM, respectively. |
|
| DC8158 | Pexidartinib(PLX3397) Featured | PLX3397 is a tyrosine kinase inhibitor that potently inhibits the colony stimulating factor 1 (CSF1) receptor kinase, a driving force in the development and growth of PVNS. |
|
| DC1071 | Vemurafenib (PLX4032) Featured | PLX4032 (Vemurafenib, RG7204, Zelboraf, RO5185426) is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM. |
|
| DC6301 | PLX-4720 Featured | PLX4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf. |
|
| DC10786 | PLX51107 Featured | PLX51107 is a novel BET inhibitor with a unique binding mode in the acetylated lysine binding pocket of BRD4 that differentiates it from other compounds under investigation. |
|
| DC11373 | Polmacoxib | Polmacoxib is an inhibitor of cyclooxygenase 2 (COX-2) and the carbonic anhydrase subtypes I (CAI) and CAII. |
|
| DC9742 | Ponesimod Featured | Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. |
|
| DCAPI1093 | Posaconazole Featured | Posaconazole (Noxafil) is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM. |
|
| DC11914 | Poseltinib Featured | Poseltinib (HM-71224, LY-3337641) is a potent and selective, covalent inhibitor of Btk with IC50 of 1.95 nM. |
|
| DC7704 | Poziotinib Featured | Poziotinib, is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity. |
|
| DC7280 | Pracinostat(SB939) Featured | Pracinostat(SB939) is a potent pan-HDAC inhibitor with IC50 of 40-140 nM with exception for HDAC6; has no activity against the class III isoenzyme SIRT I. |
|
| DC9359 | Pralatrexate Featured | Pralatrexate(Folotyn) is an antifolate, and structurally a folate analog. |
|
| DC8970 | Pramipexole Base | Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS). |
|
| DC3151 | Pramipexole dihydrochloride | Pramipexole is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM. |
|
| DCAPI1305 | Pramiracetam | Pramiracetam |
|
| DCAPI1473 | Pregabalin Featured | Pregabalin |
|
| DC9902 | PRIMA-1 Featured | PRIMA-1 is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A. |
|
| DC10070 | PRIMA-1MET(APR-246) Featured | PRIMA-1MET is methylated derivative of PRIMA-1. It can restore mutant p53 activity. |
|
| DC10641 | PRN1371 Featured | PRN1371 is an irreversible covalent FGFR1-4 kinase inhibitor, with IC50s of 0.6, 1.3, 4.1, 19.3 and 8.1 nM for FGFR1, 2, 3, 4 and CSF1R, respectively. |
|
| DC6903 | Lapaquistat Acetate (TAK-475) | Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs. |
|
| DC4121 | PSI6130 Featured | PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor. PSI-6130(R 1656) is useful for Antiviral agents. |
|
| DC10464 | PT2385 Featured | PT2385 is an orally active, small molecule inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. |
|
| DC7992 | PX 12 Featured | PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1(Trx-1) currently in clinical development as an antitumor agent; IC50=7 uM in Hela, MTT assay, 72 h. |
|
| DC7486 | PX-478 2HCL Featured | PX-478 is an inhibitor of HIF-1a with an IC50 of 20-30μM enhances radiosensitivity of prostate carcinoma cells. |
|
