| Cat. No. | Product Name | Field of Application | Chemical Structure |
|---|---|---|---|
| DC7266 | Rilpivirine(R 278474, TMC 278) Featured | Rilpivirine(R 278474, TMC 278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). |
|
| DC7268 | Risperidone(R 64 766) | Risperidone(R 64 766) is a serotonin 5-HT2 receptor blocker(Ki= 0.16 nM) and a potent dopamine D2 receptor antagonist(Ki= 1.4 nM). |
|
| DC9475 | Ritonavir Featured | Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS,showed potent activity against COVID-19(SARS-COV-2) . |
|
| DC5108 | BAY 59-7939 (Rivaroxaban) Featured | Rivaroxaban (Xarelto; BAY 59-7939) is a novel, oral, direct Factor Xa (FXa) inhibitor in late-stage development for the prevention and treatment of thromboembolic disorders. |
|
| DCAPI1435 | Rivastigmine tartrate | Rivastigmine hydrogen tartrate is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and Parkinson's disease. |
|
| DC5146 | RN486 Featured | RN-486 is a Bruton's tyrosine kinase (Btk) inhibitor. |
|
| DC9454 | Ro 28-1675 | Ro 28-1675 (Ro 0281675) is a potent allosteric GK activator with a SC1.5 value of 0.24± 0.0019 uM. |
|
| DC9666 | Ro 46-2005 Featured | Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220 nM. |
|
| DC7933 | Ro 48-8071 fumarate Featured | Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity. |
|
| DC8215 | RO4929097 Featured | RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. |
|
| DC10583 | RO 5028442 Featured | RO5028442 is a highly potent and selective Brain-Penetrant Vasopressin 1a (V1a) receptor antagonist with Kis of 1 nM (hV1a) and 39 nM (mV1a). |
|
| DC7489 | RO5126766(CH5126766) | RO5126766(CH5126766) is a Raf/MEK dual kinase inhibitor. |
|
| DC12353 | Roniciclib (BAY 1000394) | Roniciclib is an orally bioavailable pan-cyclin dependent kinase (CDK) inhibitor, with IC50s of 5-25 nM for CDK1, CDK2, CDK3, CDK4, CDK7 and CDK9. |
|
| DC4124 | ROSCOVITINE(Seliciclib) Featured | Roscovitine (Seliciclib, CYC202, R-roscovitine) is a potent and selective CDK inhibitor for Cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p53 with IC50 of 0.65 μM, 0.7 μM, 0.7 μM and 0.16 μM, respectively. |
|
| DC9084 | Rosiglitazone base | Rosiglitazone(BRL-49653) is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ(PPARγ). |
|
| DC7490 | Rostafuroxin Featured | Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. |
|
| DC5015 | Rotigotine Hydrochloride | Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic α2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
|
| DC11671 | RPL-554 | RPL-554 (LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively. |
|
| DC10036 | RRx-001 Featured | RRx-001 is a novel epigenetic modulator with potential radiosensitizing activity. It inhibits glucose 6-phosphate dehydrogenase(G6PD) in human tumor cells, binds hemoglobin and drives RBC-mediated redox reactions under hypoxia. |
|
| DC10006 | RSV-604 Featured | RSV604 is a novel inhibitor of respiratory syncytial virus replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) inhibitor in phase 2 clinical trials. |
|
| DC8198 | RTA-408(Omaveloxolone) Featured | RTA-408 is a synthetic triterpenoid that potently activates the antioxidative transcription factor Nrf2 and inhibits the proinflammatory transcription factor NF-κB. |
|
| DC5151 | Rucaparib phosphate (AG-14699, PF-01367338) Featured | Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM with binding affinity to nine PARP domains. Phase 1/2. |
|
| DC8464 | Rucaparib(AG-014447) Featured | Rucaparib inactivates PARP activity in cells with homologous recombination DNA repair pathway mutations at LC50 values ranging from 1.3-5.5 μM. |
|
| DC4230 | Ruxolitinib (INCB018424) Featured | Ruxolitinib is a potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively and is relatively less selective for JAK3 (IC50 = 322 nM). |
|
| DC8309 | Ruxolitinib Phosphate Featured | Ruxolitinib Phosphate is a potent and selective Janus kinase (JAK1, IC50 = 5.9 nM and JAK2, IC50 = 5.7 nM) inhibitor. |
|
| DC7762 | RX-3117 Featured | RX-3117 is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. |
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| DC10479 | RX518(CK-101:EGFR-IN-3) Featured | RX518(CK-101) is an orally available third-generation and selective inhibitor of certain epidermal growth factor receptor (EGFR) activating mutations. |
|
| DC7274 | S1RA Featured | S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM), showed good selectivity against σ2R (Ki > 1000 nM). |
|
| DC9264 | S1RA hydrochloride Featured | S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM), showed good selectivity against σ2R (Ki > 1000 nM). |
|
| DC11176 | S44819 | S44819 (S 44819, Egis-13529) is a novel potent, competitive, selective antagonist of the α5-GABAAR with Kd of 221 nM, IC50 of 585 nM (α5β2γ2). |
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