| DC60352 |
DDAB |
Dimethyldioctadecylammonium bromide (DDAB) is a cationic surfactant that is used as an antimicrobial agent. |
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| DC60358 |
EDOPC
Featured
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| DC60361 |
DLin-K-DM4 |
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| DC60362 |
DLenDMA
Featured
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DlenDMA is a lipid for RNA and vaccine delivery. DLenDMA showed better siRNA transfection efficiency than DODMA. |
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| DC60363 |
DOSPER
Featured
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| DC60364 |
GL67 |
GL 67 (N4-Spermine cholesteryl carbamate) is a cationic lipid. GL-67 can be used for nucleic acid agents and vaccines delivery, and gene transfection[1]. Genzyme Lipid (GL67), The cationic lipid N4 -cholesteryl-spermine is one of the most effective non-viral gene carriers comprising spermine as a headgroup that bond in a T-shape configuration to a cholesterol anchor. |
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| DC60365 |
BGTC |
BGTC is a non-amino acid cationic lipid. BGTC can be used for delivery of nucleic acids. |
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| DC60366 |
DLinDAP |
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| DC60367 |
EDLPC
Featured
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| DC60388 |
C2-DLinDMA |
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| DC60390 |
DLin-K-C4-DMA |
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| DC83230 |
TNT-b10
Featured
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TNT-b10 is a novel Lipid-like compound suitable for delivery of siRNA and mRNA both in vitro and in vivo TNT-b10 LLNs was more than 10-fold more potent than TNT-a10 LLNs formulated under the same condition. |
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| DC72701 |
mono-Pal-MTO |
mono-Pal-MTO is a palm oil-based lipid produced by combining the anticancer drug mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity. |
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| DC72708 |
di-Pal-MTO |
di-Pal-MTO is a palm oil-based lipid produced by combining the anticancer drug mitoxantrone (MTO) with palmitoleic acid. When nanoparticles of mono-Pal-MTO and di-Pal-MTO are combined in a molar ratio of 1:1, they show effective siRNA cell delivery and enhance anticancer activity. |
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| DC83220 |
ALC-0315 analgous-1
Featured
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ALC-0315 analgous-1 is an ethanolamine ionizable lipid with both ester bonds located adjacent to C8 relative to the amine head. The introduction of ester linkages can improve the clearance of the lipid in the liver. This compound is analgous to ALC-0315. |
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| DC60405 |
C13-112-tri-tail |
C13-112-tri-tail is an ionizable lipid molecule containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a PEG2 linker. The lipoid can be formulated into a lipid nanoparticle (LNP) to deliver anionic substrates in vitro and in vivo. This includes siRNA to induce gene silencing in a sequence-specific manner, CAS9 mRNA, and cytotoxic proteins. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries. |
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| DC60406 |
C13-113-tri-tail |
C13-113-tri tail is an ionizable lipid molecule containing a polar amino alcohol head group, three hydrophobic carbon-13 tails, and a tertiary amine linker. The lipoid can be formulated into a lipid nanoparticle (LNP) to deliver anionic substrates in vitro and in vivo. This includes siRNA to induce gene silencing in a sequence-specific manner, CAS9 mRNA, and cytotoxic proteins. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries. |
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| DC60407 |
C13-112-tetra-tail |
C13-112-tetra-tail is an ionizable lipid molecule containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a PEG2 linker. The lipoid can be formulated into a lipid nanoparticle (LNP) to deliver anionic substrates in vitro and in vivo. |
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| DC60408 |
C13-113-tetra-tail |
C13-113-tetra tail is an ionizable lipid molecule containing a polar amino alcohol head group, four hydrophobic carbon-13 tails, and a tertiary amine linker. |
|
| DC60421 |
DC-6-14 |
DC-6-14 is a cationic lipid that can be used for drug delivery, gene transfection and vaccine delivery. DC-6-14 may be used for research into in vitro and in vivo nucleic acid and protein delivery. Reagent grade, for research use only.
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| DC84101 |
Arcturus lipid 2 analog((Lipid 2,2 (9,9) 4C CH3))
Featured
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Arcturus lipid 2 analog (Lipid 2,2 (9,9) 4C CH3) is an analog of Arcturus lipid 2((Lipid 2,2 (8,8) 4C CH3)) with chain adjusted to C9 instead of C8. |
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| DC84110 |
R-DOTAP(DOTAP R-isomer ) |
1,2-Dioleoyl-3(R)-trimethylammoniumpropane (R-DOTAP) is a cationic lipid and the more immunologically active isomer of DOTAP.Lipoplexes containing R-DOTAP and encapsulating siRNA targeting the gene encoding aromatase, CYP19A1, decrease aromatase activity in MCF-7 breast cancer cells.1 Vaccination with a peptide epitope from human papillomavirus (HPV) 16 protein E7 in R-DOTAP-containing liposomes induces IFN-γ production by CD8+ T cells and tumor-infiltrating lymphocytes (TILs) and decreases tumor size in a murine cervical cancer model.2 Subcutaneous immunization with recombinant influenza B hemagglutinin using R-DOTAP as an adjuvant increases IL-2 and IFN-γ production in CD4+ T cells isolated from mouse draining lymph nodes and spleen. |
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| DC65001 |
4A3-Cit
Featured
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4A3-Cit is an ionizable lipid used for the generation of lipid nanoparticles (LNPs). To investigate the role of unsaturated lipid tails in iLNPs, the
nucleophilic amines were added to ester-based linkers, followed
by Michael’s addition to the thiols to construct a library of 91
amino ionizable lipids. Such ionizable lipids were composed
of an ionizable tertiary amine core, an ester-based degradable
linker, and an alkylthiol tail periphery. Through in vitro
and in vivo screening, the iLNPs with 4A3 core and citronellolbased
(Cit) periphery can significantly increase endosome escape
and delivery efficiency of mRNA, leading to 18-fold increase in
protein expression compared with iLNPs without Cit periphery.
Furthermore, the delivery efficiency of mRNA may be associated
with the location/configuration of the unsaturated bond(s) in
lipids. Although lipids with Cit periphery showed excellent
membrane fusion ability to facilitate endosome escape, the
fusion mechanism needs to be further clarified. |
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| DC65004 |
G0-C14 |
G0-C14 is a cationic lipid-like compound alkyl-modified polyamidoamine (PAMAM) dendrimer. G0-C14 involves in the preparation of a series of macrophage-targeted nanoparticles (NPs). NPs can be used for drug and vaccine delivery[1][2]. |
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| DC85555 |
YK009
Featured
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YK-009 is a novel ionizable lipid for mRNA delivery. Comparisons of YK009-LNP-mRNA and commercial MC3-LNP-mRNA showed that YK009-LNP-mRNA vaccines had good biodistribution patterns, favorable tissue clearance, and high delivery efficiency. Furthermore, our study proved that YK009-LNP-Omicron mRNA could trigger a robust immune response and immune protection against the SARS-CoV-2 Omicron variant. |
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| DC85600 |
Lipidoid S14 |
Lipidoid S14 is a novel lipidoid for siRNA delivery.Lipidoid-polymer hybrid nanoparticle (FS14-NP) can efficiently deliver siRNA against IL-1β (siIL-1β) to macrophages and effectively suppress the pathogenesis of experimental arthritis induced by collagen antibody (CAIA mice). FS14-NP/siIL-1β achieved approximately 70% and 90% gene-silencing efficiency in the RAW 264.7 cell line and intraperitoneal macrophages, respectively. Intravenous administration of FS14-NP/siRNA led to rapid accumulation of siRNA in macrophages within the arthritic joints. Furthermore, FS14-NP/siIL-1β treatment lowered the expression of pro-inflammatory cytokines in arthritic joints and dramatically attenuated ankle swelling, bone erosion, and cartilage destruction. |
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| DC86601 |
Lipid 8
Featured
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Lipid 8 iLNPs were used to
deliver CRISPR-Cas9 mRNA and sgRNA which targeted to the
PLK1 gene. The safety and excellent intracerebral diffusion
performance of lipid 8 iLNPs ensured that the survival of
murine glioblastoma multiforme (GBM) mice was extended.
The median survival was extended by approximately 50% and
the overall survival was increased by 30%. The treatment of
metastatic adenocarcinoma was executed by the EGFRtargeted
lipid 8 iLNPs. These iLNPs possessed the ability of
tumor targeting, which could increase the accumulation of
CRISPR-Cas9 mRNA and sgRNA within the tumor cells.
After a single intraperitoneal administration, 80% PLK1 gene
was edited and the overall survival of mice with high-grade
ovarian cancer malignant ascites was enhanced by 80%
. These results demonstrate the clinical potential
of CRISPR-Cas9 gene editing system can be delivered by
iLNPs for treating tumors, and provide new ideas for tumor
gene therapy. |
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| DC65178 |
AL-A12 |
AL-A12 is an ionizable cationic amino lipid that has been used in the formation of lipid nanoparticles (LNPs).1 LNPs containing AL-A12 and encapsulating minicircle DNA that encodes for GFP have been used to induce GFP expression in Huh7 cells. |
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| DC65179 |
Dlin-MC4-DMA
Featured
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D-Lin-MC4-DMA(MC4) is a cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA. |
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| DC65180 |
DLin-MC2-DMA
Featured
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D-Lin-MC2-DMA(MC2) is a cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA. |
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