| DC10463 |
Repotrectinib(TPX-005)
Featured
|
Repotrectinib(TPX-005) is a multi-target macrocycle inhibitor of anaplastic lymphoma kinase (ALK), c-ros proto-oncogene 1 receptor tyrosine kinase (ROS1), and neurotrophic tyrosine kinase receptor (TRK) |
|
| DC7489 |
RO5126766(CH5126766) |
RO5126766(CH5126766) is a Raf/MEK dual kinase inhibitor. |
|
| DC7290 |
Semaxanib (SU5416)
Featured
|
Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR. |
|
| DC7294 |
SGX-523
Featured
|
SGX-523 is a selective Met inhibitor with IC50 of 4 nM, no activity to BRAFV599E, c-Raf, Abl and p38α. |
|
| DC11633 |
TAK-243
Featured
|
TAK-243 (MLN-7243, AOB87172) is a small-molecule, cell-permeable inhibitor of ubiquitin-activating enzyme E1 (UAE1). |
|
| DC7308 |
TAK-733
Featured
|
TAK-733 is a potent and selective MEK allosteric site inhibitor for MEK1 with IC50 of 3.2 nM, inactive to Abl1, AKT3, c-RAF, CamK1, CDK2, c-Met, etc. |
|
| DC8739 |
Talabostat mesylate |
Talabostat mesilate(PT-100; Val-boroPro) is an orally active, specific inhibitor of dipeptidyl peptidases(IC50=1 nM for DPP4), including tumor-associated fibroblast activation protein. |
|
| DC8223 |
TP-0903
Featured
|
TP-0903 is a a high-affinity Axl inhibitor with IC50 of 27 nM. |
|
| DC8884 |
Voxtalisib (XL765, SAR245409)
Featured
|
Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. |
|
| DC1077 |
ZSTK474
Featured
|
ZSTK474 is a potent pan-class I PI3K inhibitor with IC50 of 37 nM. |
|
| DC10764 |
Theliatinib (HMPL-309)
Featured
|
Theliatinib (HMPL-309) is a novel small molecule, EGFR tyrosine kinase inhibitor with potential antineoplastic and anti-angiogenesis activities. |
|
| DC10034 |
GLPG0187
Featured
|
GLPG0187 is a small molecule integrin receptor antagonist (IRA) with potential antineoplastic activity. |
|
| DC11089 |
TAS-120 (Futibatinib)
Featured
|
TAS-120 is a highly potent and selective irreversible FGFR inhibitor, effective in tumors harboring various FGFR gene abnormalities. |
|
| DC7622 |
BIBX1382
Featured
|
BIBX 1382 is a potent, selective inhibitor of EGFR tyrosine kinase (IC50 = 3 nM); displays > 1000-fold lower potency against ErbB2 (IC50 = 3.4 μM) and a range of other related tyrosine kinases (IC50 > 10 μM). |
|
| DC7488 |
RO4987655
Featured
|
RO4987655(CH-4987655) is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1/MEK1 IC50=5.2 nM), with potential antineoplastic activity. |
|
