| DC7053 |
IWR-1
Featured
|
IWR-1 (endo-IWR 1) is a Wnt pathway inhibitor with IC50 of 180 nM, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes. |
|
| DC9929 |
JK-184
Featured
|
JK-184 is a potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC50 = 30 nM). |
|
| DC10556 |
KY1220
Featured
|
KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells. |
|
| DC9880 |
KYA1797K
Featured
|
KYA1797K is a highly potent and selective Wnt/β-catenin inhibitor with IC50 of 0.75 µM (TOPflash assay). |
|
| DC8615 |
L-685,458
Featured
|
L-685,458 is a selective and Potent inhibitor of γ-secretase with IC50 value of 17 nM. |
|
| DC8493 |
NVP-LDE225(Erismodegib)
Featured
|
LDE225 (NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. Phase 3. |
|
| DC7185 |
LDE225 Diphosphate
Featured
|
LDE225 (NVP-LDE225) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. Phase 3. |
|
| DC12384 |
LF3
Featured
|
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM. |
|
| DC7186 |
LGK-974
Featured
|
LGK-974 is a potent and specific PORCN inhibitor, and inhibits Wnt signaling with IC50 of 0.4 nM. |
|
| DC7191 |
LY-2940680(Taladegib)
Featured
|
LY2940680 binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. |
|
| DC7776 |
LY-3039478 |
LY3039478 a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. |
|
| DC5036 |
LY-411575
Featured
|
LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM. |
|
| DC10926 |
LY900009
Featured
|
LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein. |
|
| DC9707 |
MK-4101
Featured
|
MK-4101 is a potent SMO Inhibitor of the Hedgehog Pathway, highly active against Medulloblastoma and Basal Cell Carcinoma. |
|
| DC3122 |
MRK003 |
MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. |
|
| DC12288 |
MRT-83 |
MRT-83 is a potent antagonist of Smo, with an IC50 in the nanomolar range. |
|
| DC9770 |
NCB-0846
Featured
|
NCB-0846 is a novel,first-in-class,orally TNIK inhibitor with an IC50 value of 21 nM,that have shown strong anti-tumor efficacy against several cancer models. |
|
| DC11327 |
NSC 668036 |
NSC 668036 is an inhibitor of the Dishevelled (Dvl) protein PDZ domain (Kd = 240 μM for mouse Dvl1 PDZ domain). |
|
| DC11992 |
PAT-048 |
PAT-048 (PAT048) is a potent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX. |
|
| DC11991 |
PAT-505 |
PAT-505 (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX. |
|
| DC7027 |
Glasdegib(PF-04449913)
Featured
|
PF-04449913 is a potent and orally bioavailable inhibitor of smoothened with IC50 of 5 nM(Gli-luciferase reporter reporter in C3H10T1/2); the hedgehog pathway inhibitor |
|
| DC8146 |
PF-5006739
Featured
|
PF-5006739 is a potent inhibitor of casein kinases 1 delta (CK1δ) and 1 epsilon (CK1ε) |
|
| DC12373 |
PF-5274857
Featured
|
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier. |
|
| DC11996 |
PF-794 |
PF-794 (PF794) is a potent, specific and ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with IC50 of 39 nM in cell-free assays. |
|
| DC10409 |
PNU-74654 |
PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC50 of 129.8 μM in NCI-H295 cell. |
|
| DC7552 |
PTC-028
Featured
|
PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification |
|
| DC7255 |
Purmorphamine
Featured
|
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM and also is an inducer of osteoblast differentiation with EC50 of 1 μM. |
|
| DC5139 |
QS 11 (QS11,BML-WN117) |
QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. |
|
| DC8215 |
RO4929097
Featured
|
RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. |
|
| DC9464 |
RU-SKI 43 (hydrochloride) |
RU-SKI 43 Hcl is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
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