LY900009|cas 209984-68-9|DC Chemicals

Cas No.:	209984-68-9
Chemical Name:	(S)-2-hydroxy-3-methyl-N-((S)-1-(((S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide
Synonyms:	LY 900009;LY-900009
SMILES:	C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C(C)C)O
Formula:	C₂₃H₂₇N₃O₄
M.Wt:	409.486
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein, inhibits Notch signalling in tumour cell lines and endothelial cells with IC50 of 0.005-20 nM; dose dependently inhibits Notch cleavage and induced apoptosis 24 h after a single 3 mg/kg oral dose in xenograft tumour models, also demonstrates inhibition of angiogenesis through formation of leaky vasculature.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC48365	RO7185876	RO7185876 is a potent and selective gamma secretase modulator as a potential treatment for Alzheimer's disease.
DC47320	FRM-024	FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease.
DC7666	MK0752	MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.
DC8215	RO4929097	RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively.
DC10926	LY900009	LY900009 (LY-900009) is an orally active small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.
DC5036	LY-411575	LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch clevage with withIC50 of 0.39 nM.
DC8615	L-685,458	L-685,458 is a selective and Potent inhibitor of γ-secretase with IC50 value of 17 nM.
DC8277	E-2012	E 2012 is a potent γ-secretase modulator.
DC7396	DAPT	DAPT(GSI-IX) is an inhibitor of γ-secretase; DAPT causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma.
DC3114	Avagacestat (BMS-708163)	BMS-708163 is a potent, selective γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, respectively.