Cat. No. | Product name | CAS No. |
DC8215 |
RO4929097
Featured
RO4929097 is a γ secretase inhibitor with IC50 of 4 nM, inhibiting cellular processing of Aβ40 and Notch with EC50 of 14 nM and 5 nM, respectively. |
847925-91-1 |
DC9464 |
RU-SKI 43 (hydrochloride)
RU-SKI 43 Hcl is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh. |
1043797-53-0 |
DC8327 |
SANT-1
Featured
SANT-1 is a membrane permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway by direct binding to Smo. |
304909-07-7 |
DC12276 |
Saridegib (IPI-926; Patidegib)
Featured
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. |
1037210-93-7 |
DC4227 |
SB216763
Featured
SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β). |
280744-09-4 |
DC7496 |
Semagacestat
Featured
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM. |
425386-60-3 |
DC10888 |
SKL2001
Featured
SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. |
909089-13-0 |
DC8391 |
Smoothened Agonist (SAG) HCl
Featured
Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells. |
2095432-58-7 |
DC9782 |
SR-3029
Featured
SR 3029 is a potent and highly specific CK1δ/CK1ε inhibitor with the IC50 of 97 nM. |
1454585-06-8 |
DC11791 |
SSTC3
SSTC3 is a novel small-molecule CK1α activator with EC50 of 30 nM (WNT-driven reporter gene assay), Kd of 32 nM. |
1242422-09-8 |
DC9301 |
TA-01
Featured
TA-01 induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction at 1 μM. Inhibits cardiomyocyte differentiation at 5 μM. Potently inhibits CK1ε, p38α, and CK1δ (IC50 values are 6.4, 6.7 and 6.8 nM respectively). |
1784751-18-3 |
DC2067 |
TDZD-8
Featured
TDZD-8 is a non-ATP competitive GSK-3β inhibitor with IC50 of 2 μM. |
327036-89-5 |
DC7680 |
IM-12
Featured
The GSK3β Inhibitor XIX, IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling. |
1129669-05-1 |
DC10472 |
Toxoflavin (PKF118-310)
Featured
Toxoflavin is an inhibitor of survivin expression and antagonist of Tcf4/b-catenin signaling |
84-82-2 |
DC1063 |
TWS119
Featured
TWS119 is a GSK-3β inhibitor with IC50 of 30 nM. |
601514-19-6 |
DC4232 |
Vismodegib (GDC-0449)
Featured
Vismodegib (formerly GDC-0449) is a hedgehog antagonist, is also an orally bioavailable small molecule with potential antineoplastic activity. |
879085-55-9 |
DC11789 |
VU-WS113
VU-WS113 is a potent inhibitor of Wnt signaling with EC50 of 80 nM that selectively potentiates CK1α kinase activity.. |
1415921-09-3 |
DC7744 |
WAY-262611
Featured
WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay. |
1123231-07-1 |
DC11132 |
Wnt-p53 inhibitor compound 2
Wnt-p53 inhibitor compound 2 is a novel inhibitor targets both Wnt signaling and ATM/p53, potently inhibits Wnt transcription (IC50=11 nM) and p53 transcription (EC50=1.9 nM). |
1448427-02-8 |
DC11017 |
ZLDI-8
Featured
ZLDI-8 (IAC-8) is a novel Notch signaling pathway inhibitor for Notch activating/cleaving enzyme ADAM-17, significantly decreases the level of NICD and accumulation of NICD in the nucleus; exhibits cytotoxic acitviity against MHCC97-H cells with IC50 of 5.32 uM, reduces the expression of pro-survival/anti-apoptosis regulators, Survivin and cIAP1/2, also increases the expression of epithelial marker E-Cadherin and reduces mesenchymal markers N-Cadherin and Vimentin in HCC cells; significantly disrupted the activity of Notch pathway in HCC cells and inhibits the epithelial-mesenchymal transition (EMT) process of HCC cells; ZLDI-8 treatment enhances the susceptibility of HCC cells to Sorafenib, Etoposide, and Paclitaxel both in vitro and in vivo. |
667880-38-8 |
DC7004 |
AR-A014418(GSK3β Inhibitor VIII)
Featured
AR-A014418 is a selective and effective GSK3β inhibitor with an IC 50 value of 104 +/- 27 nM; no significant inhibition on 26 other kinases. |
487021-52-3 |
DC7666 |
MK0752
Featured
MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2. |
471905-41-6 |