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Cyclic guanosine monophosphate-adenosine monophosphate

  Cat. No.:  DC12367   Featured
Chemical Structure
1441190-66-4
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More than 5000 active chemicals with high quality for research!
Field of application
2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1441190-66-4
Chemical Name: Cyclic guanosine monophosphate-adenosine monophosphate
Synonyms: 2'3'-Cgamp;cGAMP(2'-5');Cyclic Gp(2'-5')Ap(3'-5');Cyclic guanosine monophosphate-adenosine monophosphate;2'3'-Cyclic guanosine monophosphate-adenosine monophosphate;C20640;552Y49K43E;C(g(2',5')pa(3',5')P);c[G(2',5')pA(3',5')p];1SY;2'-o,5'-O-((Adenosine-3'-o,5'-o-diyl)bisphosphinico)guanosine;2'-O,5'-O-[(Adenosine-3'-O,5'-O-diyl)bisphosphinico]guanosine
SMILES: O[C@H]1[C@@]2([C@@](O[C@@]1(COP(=O)(O)O[C@@]3([C@@](COP(=O)(O)O2)(O[C@]([C@@H]3O)(N4C=5C(N=C4)=C(N)N=CN5)[H])[H])[H])[H])(N6C7=C(N=C6)C(=O)N=C(N)N7)[H])[H]
Formula: C20H24N10O13P2
M.Wt: 674.4113
Purity: >99.5%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a molecule in endogenous cGAMP mammalian cells which contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP. 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm and binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ)[1].
Target: Human Endogenous Metabolite
References: [1]. Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC12367 Cyclic guanosine monophosphate-adenosine monophosphate 2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.
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