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STING inhibitor C-176

  Cat. No.:  DC10960   Featured
Chemical Structure
314054-00-7
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More than 5000 active chemicals with high quality for research!
Field of application
STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 314054-00-7
Chemical Name: N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
SMILES: O1C([N+]([O-])=O)=CC=C1C(NC1=CC=C(I)C=C1)=O
Formula: C11H7In2O4
M.Wt: 358.091
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: C-176 is a strong and covalent mouse STING inhibitor.
In Vivo: Notably, treatment of Trex1−/− mice with C-176 resulted in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart. Wild-type mice on a two-week treatment with C-176 show no evident signs of overt toxicity. We next conducted a three-month trial with C-176 in Trex1−/− mice, which demonstrated marked amelioration of various signs of systemic inflammation[1].
In Vitro: C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC28013 Cyclic-di-GMP(c-di-GMP) Cyclic di-GMP (c-di-GMP) is one of the most important and common bacterial second messenger. It is involved in numerous prokaryotic processes, including biofilm formation, motility, virulence, and cell cycling. c-di-GMP also has functions in eukaryotic cells. It is detected by the transmembrane protein stimulator of interferon genes (STING), leading to activation of the innate immune system.
DC28012 c-Di-AMP(Cyclic-Di-AMP) ammonium salt Bis-(3'-5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a bacterial second messenger implicated in the control of cell wall metabolism, osmotic stress responses and sporulation. Detection of c-di-AMP by the host cytoplasmic surveillance pathway (CSP) is known to elicit type I IFN responses through a signaling axis that involves STING, TBK1 and IRF3 [1, 2]. Involvement of the helicase DDX41 in the recognition of c-di-AMP has been suggested [3]. Recent studies have also demonstrated that c-di-AMP exerts strong adjuvant activities when delivered by the mucosal route [4, 5].
DC10959 STING inhibitor C-178 STING inhibitor C-178 is a covalent, small-molecule inhibitor of STING, blocks palmitoylation (PMA)-induced clustering of STING; covalently binds to Cys91, directly targets mouse STING (mmSTING) but not human STING (hsSTING).
DC10960 STING inhibitor C-176 STING inhibitor C-178 is a covalent, in vivo-active, small-molecule inhibitor of STING
DC10908 ML RR-S2 CDA ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2'5'-phosphodiester bonds and is an activator of stimulator of interferon genes (STING).
DC10876 H-151 H-151(H151) is a novel STING (stimulator of interferon genes) antagonist.
DC12321 STING agonist-1 trihydrochloride diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist.
DC11642 Cridanimod sodium Cridanimod sodium is a potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
DC11641 Cridanimod A potent type I interferon (IFN) inducer that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
DC12367 Cyclic guanosine monophosphate-adenosine monophosphate 2'3'-cGAMP has been used to identify small compounds capable of binding human stimulator of interferon genes (STING). It is also used to study type I interferon response to cytosolic DNA.
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