AR-7|cas 80306-38-3|DC Chemicals

Cas No.:	80306-38-3
Chemical Name:	AR7
Synonyms:	AR7;AR-7;Atypical retinoid 7;AR 7 (RARalpha agonist);7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine;7-Chloro-3-p-tolyl-2H-benzo[b][1,4]oxazine
SMILES:	CC1=CC=C(C2=NC3=CC=C(Cl)C=C3OC2)C=C1
Formula:	C₁₅H₁₂ClNO
M.Wt:	257.714882850647
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

AR7 is a retinoic acid receptor α (RARα) antagonist.

In Vitro:

Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the cellular response to stress through the selective degradation of cytosolic proteins in lysosomes. Decrease in CMA activity occurs in aging and in age-related disorders. Signaling through the retinoic acid receptor alpha (RARα) inhibits CMA. AR7, an RARα antagonist, significantly activates CMA activity in mouse fibroblasts. A marked increase in CMA-activating potency is found when AR7 and GR1 are combined, supporting their cooperative effect. Treatment with the transcriptional repressor Actinomycin D partially reduces the stimulatory effect of AR7 on CMA, consistent with transcriptional changes contributing to the upregulation of CMA [1].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC28238	Fluorobexarotene	Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene.
DC10833	LY2955303	LY2955303 is a potent and selective RAR-gamma antagonist for the treatment of osteoarthritis pain.
DC7714	Fenretinide (4-HPR)	Fenretinide (4-HPR) is a synthetic retinoid deriverative. 4-HBR is shown to exhibit binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
DC10491	CD437	CD437 is a synthetic retinoid that is an RARγ-selective agonist. It displays RARγ-dependent and -independent effects on differentiation and apoptosis.
DC10135	AR-7	AR7 is a retinoic acid receptor α (RARα) antagonist.
DC7054	AM580	A retinoic acid analog and selective RARα agonist