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Anacardic Acid

  Cat. No.:  DC8322   Featured
Chemical Structure
16611-84-0
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More than 5000 active chemicals with high quality for research!
Field of application
Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF) with IC50 values of 8.5 and 5 µM, respectively.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 16611-84-0
Chemical Name: GinkgolicacidC15:0
Synonyms: Benzoic acid,2-hydroxy-6-pentadecyl-;Ginkgolic Acid (C15:0);(15:0)-Anacardic acid;2-Hydroxy-6-pentadecyl Benzoic Acid;Anacardic acid;Anacardic acid ( 6-Pentadecylsalicylic acid);Ginkgolic acid C15:0;22:0-Anacardic acid;22:0-Anacardic acid,2-Hydroxy-6-pentadecylbenzoic acid,6-Pentadecylsalicylic acid;2-pentadecyl-6-hydroxybenzoic acid;6-n-pentadecylsalicylic acid;6-Pentadecylsalicylic acid;Anarcadic Acid;cyclogallipharic acid;NSC 229596;NSC 333857;NSC 623096;6-Pentadecyl-2-hydroxybenzoic acid;Hydrogenated anacardic acid;Anachardic acid;PENTADECYLSALICYLICACID;Hodrogenated anacardic acid;2-Hydroxy-6-pentadecylbenzoic acid
SMILES: O=C(O)C1=C(CCCCCCCCCCCCCCC)C=CC=C1O
Formula: C22H36O3
M.Wt: 348.51944
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC50s of ∼8.5 μM and ∼5 μM, respectively.
In Vivo: Anacardic acid (5 mg/kg, i.p.) attenuates the binding of HATs to the promoter of MEF2A and reverse hyperacetylation of H3K9ac caused by phenylephrine in C57BL/6 mice. Anacardic acid inhibits the level of transcription on MEF2A and cardiac development-related downstream genes, attenuates the protein overexpression of cardiac downstream genes caused by phenylephrine, reverses and attenuates cardiac hypertrophy in the hearts of mice exposed to phenylephrine, and attenuates the left ventricular pressure and improves cardiac function in the cardiac hypertrophy mice[2].
In Vitro: Anacardic Acid is a histone acetyltransferase, inhibits HAT activity of p300 and PCAF, with IC50s of ∼8.5 μM and ∼5 μM, respectively[1]. Anacardic Acid (300 μM) inhibits mycelial growth. Anacardic Acid (50 μM) induces apoptosis-like characteristics in M. oryzae, and the effect is caspase independent. Anacardic Acid (1-80 μM) leads to loss of mitochondrial potential. Anacardic Acid (1-60 μM) also exhibits antioxidant activity in M. oryzae[3].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC72777 DS-9300 DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor with an IC50 value of 28 nM. DS-9300 has anticancer activity and can be used in prostate cancer disease research.
DC40724 MS117 MS117 is a first-in-class and cell-active irreversible protein arginine methyltransferase 6 (PRMT6) covalent inhibitor, with an IC50 of 18 nM.
DC12370 YF2 YF2 is a First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma.
DC10880 WM-8014 WM-8014(WM8014) is a highly potent, selective inhibitors of KAT6A and KAT6B.
DC10881 WM-1119 WM-1119(WM1119) is a highly potent, selective inhibitors of KAT6A and KAT6B.
DC7794 MG149 MG 149 is an inhibitor of histone acetyltransferases (HAT) with IC50 values of 74μM and 47μM for Tip60 and MOF, respectively.
DC8578 L002(NSC764414) L002 is a p300 inhibitor (IC50=1.98 μM) that inhibits p53 and histone acetylation. Suppresses STAT3 activation in vitro and suppresses tumor growth in some mouse cell lines.
DC9982 I-CBP112 I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively).
DC7658 C646 C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. Preferentially selective for p300 versus other acetyltransferases.
DC8322 Anacardic Acid Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF) with IC50 values of 8.5 and 5 µM, respectively.
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