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WM-8014

  Cat. No.:  DC10880   Featured
Chemical Structure
2055397-18-5
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More than 5000 active chemicals with high quality for research!
Field of application
WM-8014(WM8014) is a highly potent, selective inhibitors of KAT6A and KAT6B.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2055397-18-5
Chemical Name: WM-8014,WM 8014,WM8014,KAT6A inhibitor, KAT6B inhibitor
Synonyms: WM-8014,WM 8014,WM8014,KAT6A inhibitor, KAT6B inhibitor
SMILES: C1=CC=C(C2=CC(C(=O)NNS(=O)(=O)C3=CC=CC=C3)=C(F)C(C)=C2)C=C1
Formula: C20H17FN2O3S
M.Wt: 384.09
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: WM-8014 is an inhibitor of MOZ, a member of histone acetyltransferases, with an IC50 of 55 nM.
In Vitro: WM-8014 (Compound 36) is an inhibitor of MOZ, with an IC50 of 55 nM. WM-8014 causes cell senescence and suppresses the proliferation with IC50s of 1.6 μM and 551 nM, respectively. WM-8014 also reduces mRNA coding for the MOZ gene Cdc6 by 65.1%[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC72777 DS-9300 DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor with an IC50 value of 28 nM. DS-9300 has anticancer activity and can be used in prostate cancer disease research.
DC40724 MS117 MS117 is a first-in-class and cell-active irreversible protein arginine methyltransferase 6 (PRMT6) covalent inhibitor, with an IC50 of 18 nM.
DC12370 YF2 YF2 is a First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma.
DC10880 WM-8014 WM-8014(WM8014) is a highly potent, selective inhibitors of KAT6A and KAT6B.
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DC7794 MG149 MG 149 is an inhibitor of histone acetyltransferases (HAT) with IC50 values of 74μM and 47μM for Tip60 and MOF, respectively.
DC8578 L002(NSC764414) L002 is a p300 inhibitor (IC50=1.98 μM) that inhibits p53 and histone acetylation. Suppresses STAT3 activation in vitro and suppresses tumor growth in some mouse cell lines.
DC9982 I-CBP112 I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively).
DC7658 C646 C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. Preferentially selective for p300 versus other acetyltransferases.
DC8322 Anacardic Acid Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF) with IC50 values of 8.5 and 5 µM, respectively.
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