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Home > Inhibitors & Agonists > Epigenetics > Histone Acetyltransferase (HAT)

DS-9300

  Cat. No.:  DC72777   Featured
Chemical Structure
2259641-46-6
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More than 5000 active chemicals with high quality for research!
Field of application
DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor with an IC50 value of 28 nM. DS-9300 has anticancer activity and can be used in prostate cancer disease research.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2259641-46-6
Chemical Name: DS-9300
Synonyms: 2-Pyrrolidinecarboxamide, 1-[[4,4-difluoro-1-(4-methoxyphenyl)cyclohexyl]carbonyl]-4-fluoro-N-1H-pyrazolo[4,3-b]pyridin-5-yl-, (2R,4R)-;DS-9300
SMILES: N1(C(C2(C3=CC=C(OC)C=C3)CCC(F)(F)CC2)=O)C[C@H](F)C[C@@H]1C(NC1N=C2C=NNC2=CC=1)=O
Formula: C25H26F3N5O3
M.Wt: 501.500855922699
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_37300_DC72777
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Cat. No. Product name Field of application
DC72777 DS-9300 DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor with an IC50 value of 28 nM. DS-9300 has anticancer activity and can be used in prostate cancer disease research.
DC40724 MS117 MS117 is a first-in-class and cell-active irreversible protein arginine methyltransferase 6 (PRMT6) covalent inhibitor, with an IC50 of 18 nM.
DC12370 YF2 YF2 is a First-in-Class Histone Acetyltransferase (HAT) Activators for Precision Targeting of Epigenetic Derangements in Lymphoma.
DC10880 WM-8014 WM-8014(WM8014) is a highly potent, selective inhibitors of KAT6A and KAT6B.
DC10881 WM-1119 WM-1119(WM1119) is a highly potent, selective inhibitors of KAT6A and KAT6B.
DC7794 MG149 MG 149 is an inhibitor of histone acetyltransferases (HAT) with IC50 values of 74μM and 47μM for Tip60 and MOF, respectively.
DC8578 L002(NSC764414) L002 is a p300 inhibitor (IC50=1.98 μM) that inhibits p53 and histone acetylation. Suppresses STAT3 activation in vitro and suppresses tumor growth in some mouse cell lines.
DC9982 I-CBP112 I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively).
DC7658 C646 C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. Preferentially selective for p300 versus other acetyltransferases.
DC8322 Anacardic Acid Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (pCAF) with IC50 values of 8.5 and 5 µM, respectively.
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