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Home > Inhibitors & Agonists > GPCR > Sigma Receptor

BD1047.2HBr

  Cat. No.:  DC8313   Featured
Chemical Structure
138356-21-5
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More than 5000 active chemicals with high quality for research!
Field of application
BD 1047 dihydrobromide is a selective antagonist of σ receptors.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 138356-21-5
Chemical Name: BD1047 HBr
Synonyms: BD 1047 dihydrobromide;dihydrobromide;N'-[2-(3,4-dichlorophenyl)ethyl]-N,N,N'-trimethylethane-1,2-diamine;BD-1047 (dihydrobromide);BD1047.2HBr;N-[2-(3,4-Dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino)ethylamine dihydrobromide;BD1047dihydrobromide;BD1047 dihydrobromide;BCP15756;API0007828;AK200110;BD 1047 dihydrobromide, >=95% (HPLC);B6521;A13196;J-0;BD-1047 dihydrobromide
SMILES: Br[H].Br[H].ClC1=C(C([H])=C([H])C(=C1[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[H])Cl
Formula: C13H22Br2Cl2N2
M.Wt: 437.041
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
In Vivo: BD 1047 does not decrease amphetamine-induced hyperactivity in mice in a statistically significant manner. BD 1047 does not modify the hyperactivity induced by NMDA receptor antagonists. BD 1047 shows a moderate activity in models used in this study suggesting that its usefulness as an antipsychtic drug is doubtful. [1]
In Vitro: Moreover, Progesterone and BD 1047 (a sigma 1 receptor antagonist) counteracted the antidepressant-like effect induced by co-administration of Pramipexole and Sertraline (but not Pramipexole and Fluoxetine). [2] This increased pNR1 expression is significantly reduced by pretreatment with the specific Sig-1 R antagonist, BD-1047. In another set of experiments Sig-1 R agonists further potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity and this is also reversed with BD-1047.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC9264 S1RA hydrochloride S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM), showed good selectivity against σ2R (Ki > 1000 nM).
DC7274 S1RA S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM), showed good selectivity against σ2R (Ki > 1000 nM).
DC8347 PRE-084 hydrochloride PRE-084 hydrochloride is a high affinity, selective σ1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively).
DC10455 NE-100 NE100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1,
DC10280 BD1063 dhydrochloride BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.
DC8313 BD1047.2HBr BD 1047 dihydrobromide is a selective antagonist of σ receptors.
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