BD1063 dhydrochloride|cas 206996-13-6

Cas No.:	206996-13-6
Chemical Name:	1-[2-(3,4-dichlorophenyl)ethyl]-4-methyl-piperazine, dihydrochloride
Synonyms:	206996-13-6 (HCl), 150208-28-9 (free base),
SMILES:	CN1CCN(CCC2=CC=C(Cl)C(Cl)=C2)CC1.[H]Cl.[H]Cl
Formula:	C₁₃H₂₀Cl₄N₂
M.Wt:	346.117
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.

In Vivo:

BD1063 dose-dependently reduces ethanol self-administration in sP rats (3.3-11 mg/kg) and withdrawn, dependent Wistar rats (4-11 mg/kg) at doses that does not modify mean ethanol self-administration in non-dependent Wistar controls. BD1063 also reduces the breakpoints of sP rats to work for ethanol under a progressive-ratio reinforcement schedule[1]. BD1063 dose-dependently reduces binge-like eating and the regularity of food responding, and blocks the increased eating rate in Palatable rats. In the light/dark conflict test, BD1063 antagonizes the increased time spent in the aversive compartment and the increased intake of the palatable diet, without affecting motor activity[2]. The administration of BD1063 30 minutes before each paclitaxel dose prevents the development of cold and mechanical allodynia in WT mice. Moreover, the acute administration of BD1063 dose dependently reverses both types of paclitaxel-induced allodynia[3].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC9264	S1RA hydrochloride	S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM), showed good selectivity against σ2R (Ki > 1000 nM).
DC7274	S1RA	S1RA(E-52862) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM), showed good selectivity against σ2R (Ki > 1000 nM).
DC8347	PRE-084 hydrochloride	PRE-084 hydrochloride is a high affinity, selective σ1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively).
DC10455	NE-100	NE100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1,
DC10280	BD1063 dhydrochloride	BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.
DC8313	BD1047.2HBr	BD 1047 dihydrobromide is a selective antagonist of σ receptors.