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| Cas No.: | 101155-02-6 |
| Chemical Name: | 9H-Purin-6-amine,9-[(2-fluorophenyl)methyl]-N-methyl- |
| Synonyms: | 9H-Purin-6-amine,9-[(2-fluorophenyl)methyl]-N-methyl-;9-(2-fluorobenzyl)-6-(methylamino)-9H-purine;9-[(2-fluorophenyl)methyl]-N-methylpurin-6-amine;BW-A-78U;9-[(2-Fluorophenyl)methyl]-N-methyl-9H-purin-6-amine;BW-A 78U |
| SMILES: | CNC1=C2N=CN(CC3=CC=CC=C3F)C2=NC=N1 |
| Formula: | C13H12N5F |
| M.Wt: | 257.26628 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. |
| In Vitro: | BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. BW-A 78U fails to significantly inhibit arachidonate release. BW-A 78U is ineffective to inhibit the lipopolysaccharide (LPS)-induced TNF-α release[1]. |
| Cell Assay: | Mononuclear cells are incubated for 30 min with BW-A 78U at the concentration of 10 nM to 10 μM. The cells are then stimulated with lipopolysaccharide (10 μg/mL) overnight at 37°C in an atmosphere of 5% CO2 at 100% humidity. Cell-free supernatants are collected, centrifuged (2000 g), and stored frozen at -20°C before TNF-α determination. TNF-α concentrations in cell culture supernatants are determined by specific ELISA using a commercial kit. Sensitivity of the assay is 1 pg/mL. The absorbance at 450 nm is assessed with an ELISA reader[1]. |
| References: | [1]. Boichot E, et al. Anti-inflammatory activities of a new series of selective phosphodiesterase 4 inhibitors derivedfrom 9-benzyladenine. J Pharmacol Exp Ther. 2000 Feb;292(2):647-53. |
MSDS
COA
| LOT NO. | DOWNLOAD |
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| 2018-0101 |
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| 2018-0101 |
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