Home > Products > Featured products

BW-A 78U

  Cat. No.:  DC12041   Featured
Chemical Structure
101155-02-6
For research use only. We do not sell to patients.
We match the best price and quality on market.
Email:order@dcchemicals.com  sales@dcchemicals.com
Tel:+86-021-58447131
Get Quotation Now
We are official vendor of:
  • 20
  • 19
  • 18
  • 17
  • 16
  • 15
  • 14
  • 12
  • 11
  • 10
  • 9
  • 8
  • 13
  • 6
  • 5
  • 4
  • 3
  • 2
  • 1
More than 5000 active chemicals with high quality for research!
Field of application
BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 101155-02-6
Chemical Name: 9H-Purin-6-amine,9-[(2-fluorophenyl)methyl]-N-methyl-
Synonyms: 9H-Purin-6-amine,9-[(2-fluorophenyl)methyl]-N-methyl-;9-(2-fluorobenzyl)-6-(methylamino)-9H-purine;9-[(2-fluorophenyl)methyl]-N-methylpurin-6-amine;BW-A-78U;9-[(2-Fluorophenyl)methyl]-N-methyl-9H-purin-6-amine;BW-A 78U
SMILES: CNC1=C2N=CN(CC3=CC=CC=C3F)C2=NC=N1
Formula: C13H12N5F
M.Wt: 257.26628
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM.
In Vitro: BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. BW-A 78U fails to significantly inhibit arachidonate release. BW-A 78U is ineffective to inhibit the lipopolysaccharide (LPS)-induced TNF-α release[1].
Cell Assay: Mononuclear cells are incubated for 30 min with BW-A 78U at the concentration of 10 nM to 10 μM. The cells are then stimulated with lipopolysaccharide (10 μg/mL) overnight at 37°C in an atmosphere of 5% CO2 at 100% humidity. Cell-free supernatants are collected, centrifuged (2000 g), and stored frozen at -20°C before TNF-α determination. TNF-α concentrations in cell culture supernatants are determined by specific ELISA using a commercial kit. Sensitivity of the assay is 1 pg/mL. The absorbance at 450 nm is assessed with an ELISA reader[1].
References: [1]. Boichot E, et al. Anti-inflammatory activities of a new series of selective phosphodiesterase 4 inhibitors derivedfrom 9-benzyladenine. J Pharmacol Exp Ther. 2000 Feb;292(2):647-53.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC9847 Vesnarinone(OPC8212) Vesnarinone is a quinolinone derivative, and its pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux.
DC7945 TAK-063 TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM; >15000-fold selectivity over other PDEs.
DC9779 Sildenafil citrate Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.
DC8048 SEP-0372814 SEP-0372814 is a potent PDE10 inhibitor.
DC4146 Roflumilast Roflumilast (Daxas) is a selective inhibitor of PDE4 with IC50 of 0.2-4.3 nM.
DC7247 PF-8380 PF-8380 is a potent and specofic autotaxin inhibitor with an IC50 value of 2.8 nM.
DC7201 PF-2545920(MP-10) PF-2545920 a highly selective and potent PDE10A inhibitor with an IC50 of 0.37 nM.
DC11367 PF-04447943 PF-04447943 is a brain-permeable phosphodiesterase (PDE) inhibitor that is selective for PDE9A (IC50 = 12 nM) over other PDEs (IC50s = >940 nM) in enzymatic assays of second messenger hydrolysis.
DC9577 Olprinone (Hydrochloride) Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor.
DC7676 IBMX(NSC165960; SC2964) IBMX(NSC165960; SC2964) is a competitive nonselective PDEs inhibitor with IC50 of 2-50 uM but does not inhibit PDE8 or PDE9; nonselective adenosine receptor antagonist.
X
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Site Map|Privacy PolicyCopyright © 2018-2020 All Rights Reserved. Technical Support:KuuJia