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Biphenylindanone A

  Cat. No.:  DC28980   Featured
Chemical Structure
866823-73-6
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More than 5000 active chemicals with high quality for research!
Field of application
Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 866823-73-6
SMILES: CC1=C(C=C2CC(C(=O)C2=C1C)C3CCCC3)OCC4=CC(=CC=C4)C5=CC=C(C=C5)C(=O)O
Formula: C30H30O4
M.Wt: 454.56
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Biphenylindanone A (BINA) is a selective human mGluR2 (hmGluR2) potentiator for the treatment of many neurological disorders[1].
Target: mGluR2
In Vitro: Biphenylindanone A (BINA) shows activity on glutamate-induced scintillation proximity assay [3H]IP1 hydrolysis on WT mGluR2 (EC50=1.57 μM) in the absence or presence of 5 μM glutamate[1].
References: [1]. Rowe BA, et al. Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site. J Pharmacol Exp Ther. 2008 Jul;326(1):240-51.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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