Brevianamide F

  Cat. No.:  DC10605   Featured
Chemical Structure
38136-70-8
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More than 5000 active chemicals with high quality for research!
Field of application
Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.
Cas No.: 38136-70-8
Chemical Name: Brevianamide F
Synonyms: (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;(3S,8aS)-3-(1H-indol-3-ylmethyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione;Brevianamide F;Cyclo(L-Pro-L-Trp);Cyclo(L-Pro-L-Trp-);Cyclo-L-tryptophyl-L-proline;L-Prolyl-L-tryptophan anhydride;Prolyltryptophanyldiketopiperazine;cyclo-L-Prolyl-L-tryptophanyl;(3S,8aS)-Hexahydro-3-(1H-indol-3-ylmethyl)pyrrolo[1,2-a]pyrazine-1,4-dione;Cyclo-L-Trp-L-Pro;cyclo-(Trp-Pro);cyclo-L-tryptophanyl-L-proline;tryptophan-proline diketopiperazine;L-tryptophyl-L-proline cyclic anhydride;AK169895;Cyclo(L-Trp-L-Pro);cyclo-(L-Trp-L-Pro);cyclo-L-proline-L-pryptophan;cyclo-L-pryptophan-L;cyclo-L-pryptophan-L-proline
SMILES: O=C1[C@]([H])(C([H])([H])C2=C([H])N([H])C3=C([H])C([H])=C([H])C([H])=C23)N([H])C([C@]2([H])C([H])([H])C([H])([H])C([H])([H])N21)=O
Formula: C16H17N3O2
M.Wt: 283.3251
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.Brevianamide F possess interesting breast cancer resistance protein inhibitory activity.[1] brevianamide F once used as aromatic substrate. [2]
References: [1]. Wauters I et al. Beyond the Diketopiperazine Family with Alternatively Bridged Brevianamide F Analogues. J Org Chem, 2015 Aug 21, 80(16):8046-54. [2]. Yin S et al. Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides. Appl Microbiol Biotechnol, 2013 Feb, 97(4):1649-60.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC71359 UR-MB108 UR-MB108 (Compound 57) is a potent, selective ABCG2 (BCRP) inhibitor with an IC50 of 79 nM. UR-MB108 is stable in blood plasma.
DC9369 YHO-13177 YHO-13177 is a potent and specific inhibitor of BCRP; potentiated the cytotoxicity of SN-38 in cancer cells and no effect on P-glycoprotein–mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells.
DC9256 KS176 KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.
DC10605 Brevianamide F Brevianamide F , also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.
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