Bromosporine|cas 1619994-69-2|DC Chemicals

Cas No.:	1619994-69-2
Chemical Name:	Bromosporine
Synonyms:	Bromosporine;Carbamic acid, N-[3-methyl-6-[4-methyl-3-[(methylsulfonyl)amino]phenyl]-1,2,4-triazolo[4,3-b]pyridazin-8-yl]-, ethyl ester;Bromorsporine;Bioomosporine;GTPL8234;C17H20N6O4S;Bromosporine, >=98% (HPLC);AOB6807;HMS3653C21;2286AH;s7233;AK175193;A4186;SW219727-1;J3.656.836D;N-[(6-3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyri
SMILES:	S(C([H])([H])[H])(N([H])C1=C(C([H])([H])[H])C([H])=C([H])C(=C1[H])C1C([H])=C(C2=NN=C(C([H])([H])[H])N2N=1)N([H])C(=O)OC([H])([H])C([H])([H])[H])(=O)=O
Formula:	C₁₇H₂₀N₆O₄S
M.Wt:	404.4435
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively.IC50 value: 0.41/0.29/0.122/0.017 uM (BRD2/BRD4/BRD9/CECR2) [1]Target: BRD inhibitorIn cell-based assays, Bromosporine (1 μM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 even at 10 μM. Bromosporine shows moderate cytotoxicity in HeLa cells at 18 μM. Bromosporine, as a chemical probe for bromodomain functional assays, will be very useful in elucidating further biological roles of reader domains.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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