Cas No.: | 425399-05-9 |
Chemical Name: | 2-[(6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol |
Synonyms: | CASIN;2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol;Cdc42 Activity-Specific Inhibitor;2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol;2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethan-1-ol;CBMicro_003660;Pirl1-related Compound 2;Oprea1_416851;AOB2878;SMSF0012088;CASIN, >=98% (HPLC);BCP15785;CB05449;AK341038 |
SMILES: | O([H])C([H])([H])C([H])([H])N([H])C1([H])C([H])([H])C([H])([H])C([H])([H])C2C3C([H])=C(C4C([H])=C([H])C([H])=C([H])C=4[H])C([H])=C([H])C=3N([H])C1=2 |
Formula: | C20H22N2O |
M.Wt: | 306.4015 |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | CASIN is a selective GTPase Cdc42 inhibitor with IC50 of 2 uM. |
In Vivo: | Reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs. |
In Vitro: | Treatment with CASIN (5 uM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells. |