DBeQ|cas 177355-84-9|supplier DC Chemicals

Cas No.:	177355-84-9
Chemical Name:	N,N'-Dibenzylquinazoline-2,4-diamine
Synonyms:	DBeq;N,N'-Dibenzyl-2,4-quinazolinediamine;JRF 12;JRF-12;N,N'-Dibenzylquinazoline-2,4-diamine;JRF;N2,N4-Dibenzylquinazoline-2,4-diamine;N,N'-Dibenzylquinazoline-2,4-diamine DBeQ;2,4-QuinazolinediaMine, N,N'-bis(phenylMethyl)-;2,4-QuinazolinediaMine, N2,N4-bis(phenylMethyl)-;N2,N4-Dibenzylquinazoline-2,4-diamine DBeQ;2-N,4-N-dibenzylquinazoline-2,4-diamine;KUC105555N;C22H20N4;MLS000769571;SMR002239188;SMR000434303;N2,N4-Dibenzyl-quinazoline-2,4-diamine;N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine;2,4-dibencilaminoquinazoline;JRF12;Oprea1_067556;Oprea1_526582;MLS006012041;MLS003568133;BDBM46584
SMILES:	N([H])(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])C1C2=C([H])C([H])=C([H])C([H])=C2N=C(N=1)N([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H]
Formula:	C₂₂H₂₀N₄
M.Wt:	340.421
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM.

In Vitro:

DBeQ is a ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively. DBeQ inhibits p97 competitively with respect to ATP, with a Ki of 3.2 ± 0.4 μM. DBeQ inhibits degradation of the p97-dependent substrate UbG76V-GFP, with IC50 value of 2.6 μM. DBeQ (10 μM) also significantly suppresses degradation of TCRα-GFP, induces CHOP but does not increase p21 level. Moreover, DBeQ inhibits the viability of MRC-5, Hek293, HeLa and RPMI8226 cells, with GI50s of 6.6 ± 2.9, 4 ± 0.6, 3.1 ± 0.5 and 1.2 ± 0.3, respectively[1]. DBeQ potently inhibits the AAA ATPase p97 by specifically binding to the ATPase site of its D2 domain (p97D2). DBeQ also inhibits Vps4, with an IC50 of 11.5 μM. Furthermore, DBeQ (30 μM) inhibits hyphal growth of the wild-type cell (strain YLZ0)[2].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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