DBeQ|cas 177355-84-9|supplier DC Chemicals

Cas No.:	177355-84-9
Chemical Name:	N,N'-Dibenzylquinazoline-2,4-diamine
Synonyms:	DBeq;N,N'-Dibenzyl-2,4-quinazolinediamine;JRF 12;JRF-12;N,N'-Dibenzylquinazoline-2,4-diamine;JRF;N2,N4-Dibenzylquinazoline-2,4-diamine;N,N'-Dibenzylquinazoline-2,4-diamine DBeQ;2,4-QuinazolinediaMine, N,N'-bis(phenylMethyl)-;2,4-QuinazolinediaMine, N2,N4-bis(phenylMethyl)-;N2,N4-Dibenzylquinazoline-2,4-diamine DBeQ;2-N,4-N-dibenzylquinazoline-2,4-diamine;KUC105555N;C22H20N4;MLS000769571;SMR002239188;SMR000434303;N2,N4-Dibenzyl-quinazoline-2,4-diamine;N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine;2,4-dibencilaminoquinazoline;JRF12;Oprea1_067556;Oprea1_526582;MLS006012041;MLS003568133;BDBM46584
SMILES:	N([H])(C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])C1C2=C([H])C([H])=C([H])C([H])=C2N=C(N=1)N([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H]
Formula:	C₂₂H₂₀N₄
M.Wt:	340.421
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DBeQ is a selective, potent, reversible, and ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively; DBeQ also inhibits Vps4 with an IC50 of 11.5 μM.

In Vitro:

DBeQ is a ATP-competitive p97 inhibitor, with an IC50 value of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A), respectively. DBeQ inhibits p97 competitively with respect to ATP, with a Ki of 3.2 ± 0.4 μM. DBeQ inhibits degradation of the p97-dependent substrate UbG76V-GFP, with IC50 value of 2.6 μM. DBeQ (10 μM) also significantly suppresses degradation of TCRα-GFP, induces CHOP but does not increase p21 level. Moreover, DBeQ inhibits the viability of MRC-5, Hek293, HeLa and RPMI8226 cells, with GI50s of 6.6 ± 2.9, 4 ± 0.6, 3.1 ± 0.5 and 1.2 ± 0.3, respectively[1]. DBeQ potently inhibits the AAA ATPase p97 by specifically binding to the ATPase site of its D2 domain (p97D2). DBeQ also inhibits Vps4, with an IC50 of 11.5 μM. Furthermore, DBeQ (30 μM) inhibits hyphal growth of the wild-type cell (strain YLZ0)[2].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

Cat. No.	Product name	Field of application
DC70000	Lysyllysyllysine	Lysyllysyllysine is a cationic moietie that may be used in the construction of gene delivery vectors and DNA nanoparticles.
DC33580	DODMA	DODMA, also known as MBN 305A is a a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery
DC33636	DOTAP	DOTAP, also known as 1,2-Dioleoyl-3-trimethylammoniumpropane, is a cationic liposome-forming compound used for transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells. It has been used in gene delivery vectors for gene ther
DC46471	RP101988	RP101988, the major active metabolite of Ozanimod, is a selective, potent S1PR1 (sphingosine-1-phosphate receptor 1) agonist, with EC50s of 0.19 nM and 32.8 nM for S1PR1 and S1PR5, respectivlely.
DC45184	Hydrofurimazine	Hydrofurimazine is a NanoLuc substrate whose enhanced aqueous solubility allows delivery of higher doses to mice. Hydrofurimazine enables sensitive bioluminescence imaging for either prolonged light production of high sensitivity.
DC37901	PD-173212	PD-173212 is a small molecule N-type calcium channel blocker.
DC37333	N,N-Diethyl-p-toluamide	N,N-Diethyl-p-toluamide is a mosquito repellent.
DC37321	AI3-15902	AI3-15902 is a biochemical.
DC37283	Methyl phenylcarbamate	Methyl phenylcarbamate is a biochemical.
DC37252	Ampyrone	Ampyrone is a metabolite of AMINOPYRINE with analgesic and anti-inflammatory properties. It is used as a reagent for biochemical reactions producing peroxides or phenols. Ampyrone stimulates LIVER MICROSOMES and is also used to measure extracellular water.