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CDN1163

  Cat. No.:  DC10948   Featured
Chemical Structure
892711-75-0
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More than 5000 active chemicals with high quality for research!
Field of application
CDN1163 (CDN-1163) is a small molecule, allosteric activator of SERCA2, dose-dependently increases the Vmax of SERCA2 Ca2+-ATPase activity in ER microsomes; increases Ca2+-ATPase activity and significantly enhances Ca2+ uptake into the ER, attenuates H2O2-stimulated cell death in HEK cells; improves glucose homeostasis and metabolic parameters, increases glucose tolerance in ob/ob mice; CDN1163 reduces lipid accumulation and decreases lipogenesis in obese mice livers.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 892711-75-0
Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
Synonyms: CDN 1163;CDN-1163
SMILES: C(NC1=C2C(=CC=C1)C=CC(C)=N2)(=O)C1=CC=C(OC(C)C)C=C1
Formula: C20H20N2O2
M.Wt: 320.392
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Krajnak K, et al. Bioorg Med Chem Lett. 2018 May 15;28(9):1591-1594. 2. Kang S, et al. J Biol Chem. 2016 Mar 4;291(10):5185-98. 3. Dahl R. Bioorg Med Chem. 2017 Jan 1;25(1):53-57. 4. Cornea RL, et al. J Biomol Screen. 2013 Jan;18(1):97-107.
Description: CDN1163 is a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activator.
Target: SERCA[1]
References: [1]. Kang S, et al. Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders. J Biol Chem. 2016 Mar 4;291(10):5185-98.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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