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Azumolene

  Cat. No.:  DC42326   Featured
Chemical Structure
64748-79-4
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Field of application
Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 64748-79-4
Chemical Name: Azumolene
Synonyms: 2,4-Imidazolidinedione,1-[[[5-(4-bromophenyl)-2-oxazolyl]methylene]amino]-;1-[[5-(4-bromophenyl)-1,3-oxazol-2-yl]methylideneamino]imidazolidine-2,4-dione;1-(((5-(4-bromophenyl)-2-oxazolyl)methylene)amino)-2,4-imidazolidinedione;1-[5-(4-bromo-phenyl)-oxazol-2-ylmethyleneamino]-imidazolidine-2,4-dione;Azumolene;Azumolene [INN];Azumoleno;Azumoleno [Spanish];Azumolenum;Azumolenum [Latin];UNII-5U7IO9CV80
SMILES: BrC1=CC=C(C2=CN=C(/C=N/N3CC(=O)NC3=O)O2)C=C1
Formula: C13H9BrN4O3
M.Wt: 349.14000
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
Description: Azumolene (EU4093 free base), a Dantrolene analog, is a muscle relaxant. Azumolene is a ryanodine receptor (RyR) modulator and inhibits the calcium-release through ryanodine receptor. Azumolene can be used for malignant hyperthermia research[1][2].
In Vivo: The effect of Azumolene (EU4093) on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg/kg. This dose of Azumolene reduces the amplitude of the twitch to 31.9% of the control value. The contraction of intrafusal muscle as measured by the response of spindle afferent discharge is also reduced by Azumolene[1].
In Vitro: Pretreatment with 20 µM Azumolene for 1-2 min inhibits SOCE activated by subsequent addition of caffeine and ryanodine to promote RyR-dependent sarcoplasmic reticulum Ca2+ store depletion in mouse myotubes and adult muscle fibers[2].
References: [1]. G C Leslie, et al. The effect of EU4093 (azumolene sodium) on the contraction of intrafusal muscle in the soleus muscle of the anaesthetized rat. Br J Pharmacol. 1989 Aug;97(4):1151-6. [2]. Viktor Yarotskyy, et al. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. PLoS One. 2013 Oct 15;8(10):e77633.
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