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VK-II-86

  Cat. No.:  DC70883   Featured
Chemical Structure
955371-84-3
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More than 5000 active chemicals with high quality for research!
Field of application
VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).VK-II-86 exhibited >2,000-fold lower beta-AR binding affinity than carvedilol.VK-II-86 prevented stress-induced ventricular tachyarrhythmias in RyR2-mutant mice and did so more effectively when combined with either of the selective beta blockers metoprolol or bisoprolol.VK-II-86 prevented hypokalaemia-induced AP prolongation and depolarization but did not alter AP parameters in normokalaemia.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 955371-84-3
Chemical Name: VK-II-86
Synonyms: VK-II-86;4-(9H-carbazol-4-yloxy)-1-[2-(2-methoxyphenoxy)ethylamino]butan-2-ol;2-Butanol, 4-(9H-carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-;methoxyphenoxy)ethylamino);methoxyphenoxy)ethylamino);GTPL10161;GTPL10161;GTPL10161;GLXC-03770;GLXC-03770;GLXC-03770;AKOS037643460;AKOS037643460;AKOS037643460;4-(9H-Carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-2-butanol;4-(9H-Carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-2-butanol;4-(9H-Carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-2-butanol;compound 8 [PMID: 24124794];compound 8 [PMID: 24124794];compound 8 [PMID: 24124794];AS-16495;AS-16495;AS-16495;4-((9H-carbazol-4-yl)oxy)-1-((2-(2-methoxyphenoxy)ethyl)amino)butan-2-ol;4-((9H-carbazol-4-yl)oxy)-1-((2-(2-methoxyphenoxy)ethyl)amino)butan-2-ol;4-((9H-carbazol-4-yl)oxy)-1-((2-(2-methoxyphenoxy)ethyl)amino)butan-2-ol;CS-0033973;CS-0033973;CS-0033973;4-(9H-carbazol-4-yloxy)-1-(2-(2- methoxyphenoxy)ethylamino) butan-2-ol;4-(9H-carbazol-4-yloxy)-1-(2-(2- methoxyphenoxy)ethylamino) butan-2-ol;4-(9H-carbazol-4-yloxy)-1-(2-(2-;4-(9H-carbazol-4-yloxy)-1-(2-(2- methoxyphenoxy)ethylamino) butan-2-ol;4-(9H-carbazol-4-yloxy)-1-(2-(2-;NCGC00388561-04;4-(9H-carbazol-4-yloxy)-1-(2-(2-;NCGC00388561-04;EX-A4685;NCGC00388561-04;EX-A4685;DA-68614;EX-A4685;DA-68614;BDBM50411862;DA-68614;BDBM50411862;955371-84-3;BDBM50411862;955371-84-3;4-(9H-CARBAZOL-4-YLOXY)-1-{[2-(2-METHOXYPHENOXY)ETHYL]AMINO}BUTAN-2-OL;955371-84-3;4-(9H-CARBAZOL-4-YLOXY)-1-{[2-(2-METHOXYPHENOXY)ETHYL]AMINO}BUTAN-2-OL;HY-111013;4-(9H-CARBAZOL-4-YLOXY)-1-{[2-(2-METHOXYPHENOXY)ETHYL]AMINO}BUTAN-2-OL;HY-111013;SCHEMBL14388550;HY-111013;SCHEMBL14388550;CHEMBL2440787;SCHEMBL14388550;CHEMBL2440787;CHEMBL2440787
SMILES: C(NCCOC1=CC=CC=C1OC)C(O)CCOC1C2C3=C(NC=2C=CC=1)C=CC=C3
Formula: C25H28N2O4
M.Wt: 420.500826835632
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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DC70883 VK-II-86 VK-II-86 is a carvedilol analogue lacking antagonist activity at β-adrenoceptors, effectively suppresses SOICR by directly reducing the open duration of the cardiac ryanodine receptor (RyR2).VK-II-86 exhibited >2,000-fold lower beta-AR binding affinity than carvedilol.VK-II-86 prevented stress-induced ventricular tachyarrhythmias in RyR2-mutant mice and did so more effectively when combined with either of the selective beta blockers metoprolol or bisoprolol.VK-II-86 prevented hypokalaemia-induced AP prolongation and depolarization but did not alter AP parameters in normokalaemia.
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