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WAY213613

  Cat. No.:  DC11145   Featured
Chemical Structure
868359-05-1
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Field of application
WAY-213613 (WAY213613) is a potent, non-substrate inhibitor of EAAT2 (GLT-1) with IC50 of 85 nM, displays > 44-fold selectivity over EAAT1 and EAAT3; also exhibits no activity towards ionotropic and metabotropic glutamate receptors.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 868359-05-1
Chemical Name: N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine
Synonyms: WAY213613;WAY-213613;WAY 213613
SMILES: C(O)(=O)[C@@H](CC(N)=O)NC1=CC=C(OC2=CC(F)=C(F)C=C2Br)C=C1
Formula: C16H13BrF2N2O4
M.Wt: 415.191
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Dunlop J, et al. Mol Pharmacol. 2005 Oct;68(4):974-82.
Description: WAY-213613 is a potent, selective human EAAT2 inhibitor (IC50, 85 nM), exhibits 59- and 45-fold selectivity over human EAAT1 and EAAT3. Inhibits glutamate uptake in rat cortical synaptosomes[1].
Target: IC50: 85 nM (Human EAAT2), 3.8 μM (Human EAAT3), 5 μM (Human EAAT1)[1]
In Vitro: WAY-213613 exhibits IC50s of 5 and 3.8 μM for EAAT1 and EAAT3, respectively[1].
References: [1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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DC11145 WAY213613 WAY-213613 (WAY213613) is a potent, non-substrate inhibitor of EAAT2 (GLT-1) with IC50 of 85 nM, displays > 44-fold selectivity over EAAT1 and EAAT3; also exhibits no activity towards ionotropic and metabotropic glutamate receptors.
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