WAY213613
Cat. No.: DC11145
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Chemical Structure
868359-05-1
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Field of application
WAY-213613 (WAY213613) is a potent, non-substrate inhibitor of EAAT2 (GLT-1) with IC50 of 85 nM, displays > 44-fold selectivity over EAAT1 and EAAT3; also exhibits no activity towards ionotropic and metabotropic glutamate receptors.
Cas No.: |
868359-05-1 |
Chemical Name: |
N-[4-(2-Bromo-4,5-difluorophenoxy)phenyl]-L-asparagine |
Synonyms: |
WAY213613;WAY-213613;WAY 213613 |
SMILES: |
C(O)(=O)[C@@H](CC(N)=O)NC1=CC=C(OC2=CC(F)=C(F)C=C2Br)C=C1 |
Formula: |
C16H13BrF2N2O4 |
M.Wt: |
415.191 |
Purity: |
>98% |
Sotrage: |
2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Publication: |
1. Dunlop J, et al. Mol Pharmacol. 2005 Oct;68(4):974-82. |
Description: |
WAY-213613 is a potent, selective human EAAT2 inhibitor (IC50, 85 nM), exhibits 59- and 45-fold selectivity over human EAAT1 and EAAT3. Inhibits glutamate uptake in rat cortical synaptosomes[1]. |
Target: |
IC50: 85 nM (Human EAAT2), 3.8 μM (Human EAAT3), 5 μM (Human EAAT1)[1] |
In Vitro: |
WAY-213613 exhibits IC50s of 5 and 3.8 μM for EAAT1 and EAAT3, respectively[1]. |
References: |
[1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13. |
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