DL-TBOA | EAAT2 Inhibitor

Cas No.:	205309-81-5
Chemical Name:	DL-TBOA
Synonyms:	D-Aspartic acid, 3-(phenylmethoxy)-, (3R)-rel-;DL-TBOA;DL-threo-β-Benzyloxyasparticacid;2-amino-3-phenylmethoxybutanedioic acid;2-Amino-3-(benzyloxy)succinic acid;(2S,3S)-2-Amino-3-benzyloxy-succinic acid;threo-beta-benzyloxyaspartic acid;D,L-threo-beta-benzyloxyaspartate;HMS3267D15;BDBM50247191;DL-2-amino-3-(benzyloxy)succinic acid;Q27166729
SMILES:	O(CC1C=CC=CC=1)C(C(=O)O)C(C(=O)O)N
Formula:	C₁₁H₁₃NO₅
M.Wt:	239.224623441696
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC73617	NV-6297	NV-6297 (NV6297) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 120 nM, directly and selectively targets GLUT-1.
DC48737	TFB-TBOA	TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC50 values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs.
DC28201	DL-TBOA	DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively.
DC11145	WAY213613	WAY-213613 (WAY213613) is a potent, non-substrate inhibitor of EAAT2 (GLT-1) with IC50 of 85 nM, displays > 44-fold selectivity over EAAT1 and EAAT3; also exhibits no activity towards ionotropic and metabotropic glutamate receptors.