TFB-TBOA|CAS 480439-73-4|DC Chemicals

Cas No.:	480439-73-4
Chemical Name:	TFB-TBOA
Synonyms:	(3S)-3-[[3-[[4-(TRIFLUOROMETHYL)BENZOYL]AMINO]PHENYL]METHOXY]-L-ASPARTIC ACID;TFB-TBOA;TFB-TBOA,(3S)-3-[[3-[[4-(Trifluoromethyl)benzoyl]amino]phenyl]methoxy]-L-asparticacid;CF3-Bza-TBOA;(2S,3S)-2-amino-3-(3-(4-(trifluoromethyl)benzamido)benzyloxy)succinic acid;(2~{s},3~{s})-2-Azanyl-3-[[3-[[4-(Trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic Acid;7O9;BDBM50327884;(2S,3S)-2-amino-3-[[3-[[4-(trifluoromethyl)benzoyl]amino]phenyl]methoxy]butanedioic acid;Not available;Toxic Solid, Organic, N.O.S. (Riluzole hydrochloride);AKOS024457151;LPWONNPEPDHEAI-GJZGRUSLSA-N;GLXC-25473;480439-73-4;SCHEMBL2490489;HY-107521;CS-0028698;CHEMBL1257519;MS-27516
SMILES:	OC(=O)[C@H]([C@@H](C(=O)O)OCC1C=C(NC(=O)C2C=CC(C(F)(F)F)=CC=2)C=CC=1)N
Formula:	C₁₉H₁₇F₃N₂O₆
M.Wt:	426.343295812607
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC73617	NV-6297	NV-6297 (NV6297) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 120 nM, directly and selectively targets GLUT-1.
DC48737	TFB-TBOA	TFB-TBOA (CF3-Bza-TBOA) is a potent glutamate transporter blocker that potently suppresses the activity of glial transporters. TFB-TBOA shows IC50 values of 22, 17, and 300 nM for glutamate transporters EAAT1, EAAT2, and EAAT3 respectively in an uptake assay using cells transiently expressing EAATs.
DC28201	DL-TBOA	DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively.
DC11145	WAY213613	WAY-213613 (WAY213613) is a potent, non-substrate inhibitor of EAAT2 (GLT-1) with IC50 of 85 nM, displays > 44-fold selectivity over EAAT1 and EAAT3; also exhibits no activity towards ionotropic and metabotropic glutamate receptors.