Poloxin-2|Poloxin 2;Poloxin2

Cas No.:	1807690-39-6
Chemical Name:	(E)-2,5-Dimethyl-4-(((2-methylbenzoyl)oxy)imino)cyclohexa-2,5-dien-1-one
Synonyms:	Poloxin 2;Poloxin2
SMILES:	C(=O)1C=C(C)/C(=N/OC(=O)C2=CC=CC=C2C)/C=C1C
Formula:	C₁₆H₁₅NO₃
M.Wt:	269.3
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM; shows >10-fold selectivity over Plk2 PBD and Plk3 PBD; significantly improved potency and selectivity over Poloxin; induces mitotic arrest and apoptosis in cultured human tumor cells at low micromolar concentrations.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC47377	PLK1-IN-2	PLK1-IN-2 is a PLK1 kinase inhibitor with an IC50 value of 0.384 μM.
DC45897	Volasertib trihydrochloride	Volasertib (BI 6727) trihydrochloride is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib trihydrochloride inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib trihydrochloride induces mitotic arrest and apoptosis. Volasertib trihydrochloride, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models.
DC45827	BTO-1	BTO-1 is a Polo-like kinase (Plk) inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications.
DC11635	Poloxin-2	A potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM.