Volasertib trihydrochloride|CAS 946161-17-7|DC Chemicals

Cas No.:	946161-17-7
Chemical Name:	Volasertib trihydrochloride
SMILES:	O=C(C1=CC=C(C(OC)=C1)NC2=NC=C(N(C3=O)C)C(N([C@@H]3CC)C(C)C)=N2)N[C@H]4CC[C@@H](CC4)N5CCN(CC5)CC6CC6.[H]Cl.[H]Cl.[H]Cl
Formula:	C₃₄H₅₃Cl₃N₈O₃
M.Wt:	728.20
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

COA

Cat. No.	Product name	Field of application
DC47377	PLK1-IN-2	PLK1-IN-2 is a PLK1 kinase inhibitor with an IC50 value of 0.384 μM.
DC45897	Volasertib trihydrochloride	Volasertib (BI 6727) trihydrochloride is an orally active, highly potent and ATP-competitive Polo-like kinase 1 (PLK1) inhibitor with an IC50 of 0.87 nM. Volasertib trihydrochloride inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib trihydrochloride induces mitotic arrest and apoptosis. Volasertib trihydrochloride, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models.
DC45827	BTO-1	BTO-1 is a Polo-like kinase (Plk) inhibitor. BTO-1 is primarily used for phosphorylation and dephosphorylation applications.
DC11635	Poloxin-2	A potent, selective PLK1 PBD inhibitor with IC50 of 1.36 uM.