GNF-351|GNF351|CAS 1227634-69-6|DC Chemicals

Cas No.:	1227634-69-6
Chemical Name:	N-(2-(3H-Indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)-7H-purin-6-amine
Synonyms:	GNF 351;GNF351
SMILES:	N1C2C(=NC(C3=CC(C)=CN=C3)=NC=2NCCC2C3=C(N=C2)C=CC=C3)N(C(C)C)C1
Formula:	C₂₄H₂₅N₇
M.Wt:	411.5
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Smith KJ, et al. J Pharmacol Exp Ther. 2011 Jul;338(1):318-27. 2. Fang ZZ, et al. Br J Pharmacol. 2014 Apr;171(7):1735-46. 3. DiNatale BC, et al. Mol Cancer Res. 2012 Oct;10(10):1369-79.

Description:

A potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential; antagonizes agonist and SAhRM-mediated suppression of SAA1, inhibit both DRE-dependent and -independent activity; decreases migration and invasion of HNSCC cells and prevents benzo[a]pyrene-mediated induction of the chemotherapy efflux protein ABCG2.

MSDS

COA

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2018-0101

Cat. No.	Product name	Field of application
DC28934	VAF347	VAF347 is a cell permeable and highly affinity aryl hydrocarbon receptor (AhR) agonist and induces AhR signaling. VAF347 inhibits the development of CD14+CD11b+ monocytes from granulo-monocytic (GM stage) precursors. VAF347 has anti-inflammatory effects.
DC28914	AhR modulator-1	AhR modulator-1 (compound 6-MCDF) is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. AhR modulator-1 inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. AhR modulator-1 also possess anti-estrogenic properties in rat uterus.
DC11794	GNF-351	GNF-351 is a potent, pure aryl hydrocarbon receptor (AHR) antagonist (IC50=62 nM) devoid of partial agonist potential; antagonizes agonist and SAhRM-mediated suppression of SAA1, inhibit both DRE-dependent and -independent activity; decreases migration and invasion of HNSCC cells and prevents benzo[a]pyrene-mediated induction of the chemotherapy efflux protein ABCG2.
DC11530	Tapinarof (Benvitimod; GSK2894512)	Tapinarof (WBI-1001) is a natural aryl hydrocarbon receptor (AhR) agonist with an EC50 of 13 nM. Tapinarof resolves skin inflammation in mice.